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Long-Term Surgical Outcomes of Temporal Lobe Epilepsy Associated With Low-Grade Brain Tumors

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dc.contributor.authorPhi, Ji Hoon-
dc.contributor.authorKim, Seung-Ki-
dc.contributor.authorCho, Byung-Kyu-
dc.contributor.authorLee, Seo Young-
dc.contributor.authorPark, Sung-joon-
dc.contributor.authorKim, Ki Joong-
dc.contributor.authorChung, Chun Kee-
dc.contributor.authorLee, Sang Kun-
dc.contributor.authorPark, Su Yeon-
dc.date.accessioned2012-06-28T01:27:10Z-
dc.date.available2012-06-28T01:27:10Z-
dc.date.issued2009-12-15-
dc.identifier.citationCANCER; Vol.115(24); 5771-5779ko_KR
dc.identifier.issn0008-543X-
dc.identifier.urihttps://hdl.handle.net/10371/77704-
dc.description.abstractBACKGROUND: Tumor-related temporal lobe epilepsy (TLE) has a high likelihood of medical intractability and requires surgical treatment. The aims of this study were to analyze the long-term surgical outcomes of and to present appropriate surgical strategies for tumor-related TLE. METHODS: The clinical data of 87 consecutive patients diagnosed with tumor-related TLE were analyzed. The median age at surgery was 22 years. Sixteen patients had a tumor confined to the amygdala or the parahippocampal gyrus, and 10 of them received a tailored lesionectomy without hippocampectomy. The surgical outcome was evaluated based on 3 aspects: seizure control, tumor control, and discontinuation of antiepileptic drugs (AEDs). RESULTS: The actuarial seizure and tumor control rates at the fifth year postoperatively were 79% and 90%, respectively. Seizure control was highly correlated with tumor control. The following factors were found to be significantly associated with poor seizure control: duration of epilepsy >10 years, presence of a remote focus on surface electroencephalography, and incomplete tumor removal. The actuarial AED maintenance rates were 47% at the second year and 11% at the fifth year. The median time to AED discontinuation was 22 months. A younger age at surgery was found to be significantly associated with an increased chance of AED discontinuation. Tailored resection focusing on the tumor resulted in a favorable outcome, even for tumors confined to the amygdala or the parahippocampal gyrus. CONCLUSIONS: Surgical treatment of tumor-related TLE resulted in long-term seizure control in the majority of patients. Maximal tumor removal can be recommended for tumor-related TLE. Cancer 2009;115:5771-9. (C) 2009 American Cancer Society.ko_KR
dc.language.isoenko_KR
dc.publisherJOHN WILEY & SONS INCko_KR
dc.subjectbrain tumorko_KR
dc.subjecttemporal lobe epilepsyko_KR
dc.subjecttailored resectionko_KR
dc.subjectseizure controlko_KR
dc.subjecttumor controlko_KR
dc.titleLong-Term Surgical Outcomes of Temporal Lobe Epilepsy Associated With Low-Grade Brain Tumorsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor피지훈-
dc.contributor.AlternativeAuthor김승기-
dc.contributor.AlternativeAuthor조병규-
dc.contributor.AlternativeAuthor이서영-
dc.contributor.AlternativeAuthor박수연-
dc.contributor.AlternativeAuthor박성준-
dc.contributor.AlternativeAuthor이상건-
dc.contributor.AlternativeAuthor김기중-
dc.contributor.AlternativeAuthor정천기-
dc.identifier.doi10.1002/cncr.24666-
dc.citation.journaltitleCANCER-
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dc.description.tc11-
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College of Medicine/School of Medicine (의과대학/대학원)Pediatrics (소아과학전공)Journal Papers (저널논문_소아과학전공)
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