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Long-Term Surgical Outcomes of Temporal Lobe Epilepsy Associated With Low-Grade Brain Tumors
DC Field | Value | Language |
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dc.contributor.author | Phi, Ji Hoon | - |
dc.contributor.author | Kim, Seung-Ki | - |
dc.contributor.author | Cho, Byung-Kyu | - |
dc.contributor.author | Lee, Seo Young | - |
dc.contributor.author | Park, Sung-joon | - |
dc.contributor.author | Kim, Ki Joong | - |
dc.contributor.author | Chung, Chun Kee | - |
dc.contributor.author | Lee, Sang Kun | - |
dc.contributor.author | Park, Su Yeon | - |
dc.date.accessioned | 2012-06-28T01:27:10Z | - |
dc.date.available | 2012-06-28T01:27:10Z | - |
dc.date.issued | 2009-12-15 | - |
dc.identifier.citation | CANCER; Vol.115(24); 5771-5779 | ko_KR |
dc.identifier.issn | 0008-543X | - |
dc.identifier.uri | https://hdl.handle.net/10371/77704 | - |
dc.description.abstract | BACKGROUND: Tumor-related temporal lobe epilepsy (TLE) has a high likelihood of medical intractability and requires surgical treatment. The aims of this study were to analyze the long-term surgical outcomes of and to present appropriate surgical strategies for tumor-related TLE. METHODS: The clinical data of 87 consecutive patients diagnosed with tumor-related TLE were analyzed. The median age at surgery was 22 years. Sixteen patients had a tumor confined to the amygdala or the parahippocampal gyrus, and 10 of them received a tailored lesionectomy without hippocampectomy. The surgical outcome was evaluated based on 3 aspects: seizure control, tumor control, and discontinuation of antiepileptic drugs (AEDs). RESULTS: The actuarial seizure and tumor control rates at the fifth year postoperatively were 79% and 90%, respectively. Seizure control was highly correlated with tumor control. The following factors were found to be significantly associated with poor seizure control: duration of epilepsy >10 years, presence of a remote focus on surface electroencephalography, and incomplete tumor removal. The actuarial AED maintenance rates were 47% at the second year and 11% at the fifth year. The median time to AED discontinuation was 22 months. A younger age at surgery was found to be significantly associated with an increased chance of AED discontinuation. Tailored resection focusing on the tumor resulted in a favorable outcome, even for tumors confined to the amygdala or the parahippocampal gyrus. CONCLUSIONS: Surgical treatment of tumor-related TLE resulted in long-term seizure control in the majority of patients. Maximal tumor removal can be recommended for tumor-related TLE. Cancer 2009;115:5771-9. (C) 2009 American Cancer Society. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | JOHN WILEY & SONS INC | ko_KR |
dc.subject | brain tumor | ko_KR |
dc.subject | temporal lobe epilepsy | ko_KR |
dc.subject | tailored resection | ko_KR |
dc.subject | seizure control | ko_KR |
dc.subject | tumor control | ko_KR |
dc.title | Long-Term Surgical Outcomes of Temporal Lobe Epilepsy Associated With Low-Grade Brain Tumors | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 피지훈 | - |
dc.contributor.AlternativeAuthor | 김승기 | - |
dc.contributor.AlternativeAuthor | 조병규 | - |
dc.contributor.AlternativeAuthor | 이서영 | - |
dc.contributor.AlternativeAuthor | 박수연 | - |
dc.contributor.AlternativeAuthor | 박성준 | - |
dc.contributor.AlternativeAuthor | 이상건 | - |
dc.contributor.AlternativeAuthor | 김기중 | - |
dc.contributor.AlternativeAuthor | 정천기 | - |
dc.identifier.doi | 10.1002/cncr.24666 | - |
dc.citation.journaltitle | CANCER | - |
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dc.description.tc | 11 | - |
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