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Loss of PTEN Expression is an Independent Poor Prognostic Factor in Non-Small Cell Lung Cancer

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Authors
Yoo, Seol Bong; Choe, Gheeyoung; Xu, Xianhua; Lee, Hyunju; Lee, Choon-Taek; Chung, Jin-Haeng; Jheon, Sanghoon
Issue Date
2010-12
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
JOURNAL OF THORACIC ONCOLOGY; Vol.5 12; S392-S392
Abstract
Introduction: The PTEN gene acts as a tumor suppressor gene and there are
various mechanisms involved to suppress its function, including mutation,
homozygous deletion, and promoter methylation. Recently, the role of PTEN
loss is focused on drug resistance mechanism, such as gefitinib. We investigated
PTEN protein expression in non-small cell lung cancer (NSCLC) and
correlated with clinicopathologic features to evaluate prognostic significance.
ISSN
1556-0864
Language
English
URI
https://hdl.handle.net/10371/77764
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College of Medicine/School of Medicine (의과대학/대학원)Pathology (병리학전공)Journal Papers (저널논문_병리학전공)
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