Midtrimester maternal plasma concentrations of angiopoietin 1, angiopoietin 2, and placental growth factor in pregnant women who subsequently develop preeclampsia

Abstract

OBJECTIVE: To compare midtrimester maternal plasma concentrations of angiopoietin 1, angiopoietin 2, and placental growth factor between pregnant women who subsequently develop preeclampsia and those who do not. STUDY DESIGN: Midtrimester maternal plasma was collected and preserved at 70°C when amniocentesis was performed. Cases included 37 samples of those who subsequently developed preeclampsia, and matched controls were from those who did not develop preeclampsia. Angiopoietin 1, angiopoietin 2, and placental growth factor concentrations were measured by ELISA method, and compared with Mann- Whitney U test. P value .05 was considered significant. RESULTS: In pregnant women who subsequently developed preeclampsia, midtrimester maternal plasma concentrations of angiopoietin 1 and angiopoietin 2 were significantly higher and placental growth factor concentration was significantly lower than those who did not develop preeclampsia (angiopoietin 1: 10610 [3074-19720] vs 7773 [862-24421] pg/mL, P .031; angiopoietin 2: 31038 [4666- 81199] vs 18445 [4199-49745] pg/mL, P .001; placental growth factor: 87.1 [14.2-774.3] vs 148.8 [57.2-425.6] pg/mL, P .001). CONCLUSION: Midtrimester maternal plasma concentrations of angiopoietin 1, angiopoietin 2, and placental growth factor is risk factors for the subsequent development of preeclampsia.