S-Space College of Medicine/School of Medicine (의과대학/대학원) Internal Medicine (내과학전공) Journal Papers (저널논문_내과학전공)
Antituberculosis drug-induced liver injury in chronic hepatitis and cirrhosis
- Park, Wan Beom; Kim, Won; Lee, Kook Lae; Yim, Jae-Joon; Jung, Yong Jin; Kim, Dong Hee; Yoon, Jung-Hwan; Lee, Hyo Suk; Oh, Myoung-don; Kim, Yoon Jun; Kim, Nam Joong; Kim, Moonsuk
- Issue Date
- W B SAUNDERS CO LTD
- JOURNAL OF INFECTION; Vol.61 4; 323-329
- Objectives: To evaluate the incidence, risk factors and outcomes for anti-tuberculosis (TB) drug-induced liver injury (DILI) in patients with chronic liver disease including cirrhosis. Methods: A total of 107 patients with chronic liver disease were assessed for anti-TB DILI. Anti-TB DILI was defined as elevation of alkaline phosphatase (ALP), aspartate transaminase, or alanine transaminase, or an increase in Child-Turcotte-Pugh score within 2 months of initiating anti-TB medication. The risk factors for anti-TB DILI were evaluated by multivariate logistic regression analysis. Results: Fifty-eight (54%) patients had cirrhosis. Of 93 patients receiving one or more hepatotoxic anti-TB drugs, 18 (17%) experienced DILI: 11 (24%) among 46 patients with chronic hepatitis and 7 (15%) among 46 patients with compensated liver cirrhosis (P = 0.271). Independent risk factors for DILI were female sex, number of hepatotoxic anti-TB drugs administered and baseline ALP levels but not cirrhosis itself. Of the 18 patients with DILI, 13 (72%) successfully completed anti-TB treatment after switching to less hepatotoxic drug regimens. Conclusions: Hepatotoxic anti-TB drugs may be safely used in the patients with chronic liver disease including compensated cirrhosis if number of hepatotoxic drugs used is adjusted appropriately. (C) 2010 The British Infection Society. Published by Elsevier Ltd. All rights reserved.
- Files in This Item: There are no files associated with this item.