S-Space College of Medicine/School of Medicine (의과대학/대학원) Surgery (외과학전공) Journal Papers (저널논문_외과학전공)
Clinical Characteristics of Gastric Cancer Associated with Pregnancy
- Lee, Hyuk-Joon; Lee, In Kyu; Kim, Jong Won; Lee, Kuhn Uk; Yang, Han-Kwang; Choe, Kuk Jin
- Issue Date
- DIGESTIVE SURGERY; Vol.26(1); 31-36
- Background/Aims: This study was conducted to evaluate the clinical features and treatment outcome of gastric cancer associated with pregnancy. Methods: Clinicopathologic characteristics of 15 patients who were diagnosed as having gastric cancer during pregnancy or within 1 year after delivery (the P-related group) were compared with those of 53 age-matched pregnancy-unrelated gastric cancer patients (the control group). Results: Significant differences were found in tumor stage and surgical curability; the numbers of stage IV disease were 12 (80%) and 21 (40%; p = 0.006), and those of curative resection were 4 (27%) and 20 (62%; p = 0.02) in the P-related and the control group, respectively. Three-year survival rate was significantly lower in the P-related group (23.3%) than in the control group (52.8%; p = 0.007). In the P-related group, only 3 patients, including one patient diagnosed using endoscopy, survived without recurrences. In the multivariate analysis, pregnancy was not identified as an independent risk factor associated with poor outcome. Conclusion: Gastric cancer associated with pregnancy is discovered at its advanced stage and consequently shows a dismal prognosis. Considering that the patients who underwent curative resection have a favorable prognosis, primary efforts should be focused on early diagnosis. Copyright (C) 2009 S. Karger AG, Basel
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