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Effect of hypoxic treatment on bone marrow cells that are able to migrate to the injured liver

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dc.contributor.authorJu, Sun-Young-
dc.contributor.authorCho, Kyung-Ah-
dc.contributor.authorCho, Su Jin-
dc.contributor.authorJung, Yun-Jae-
dc.contributor.authorSeoh, Ju-Young-
dc.contributor.authorRyu, Kyung-Ha-
dc.contributor.authorHan, Ho-Seong-
dc.contributor.authorWoo, So-Youn-
dc.date.accessioned2012-06-29T00:26:59Z-
dc.date.available2012-06-29T00:26:59Z-
dc.date.issued2009-01-
dc.identifier.citationCELL BIOLOGY INTERNATIONAL; Vol.33(1); 31-35ko_KR
dc.identifier.issn1065-6995-
dc.identifier.urihttp://hdl.handle.net/10371/77840-
dc.description.abstractRestricted numbers and poor regenerative properties limit the use of adult stem cells. We tested the effect of hypoxic treatment as a method by which to increase cell migration. Bone marrow cells (BMCs) were cultured under oxygen saturations of 0.1, 3, and 20% for 24 h. After hypoxic treatment, BMCs of apoptotic fraction were decreased. The expression of CXCR4 was noticeably increased in the hypoxia-treated BMCs and their migration in response to SDF-1 alpha was enhanced compared with cells cultured under normoxic condition. Hypoxic BMCs had a higher degree of engraftment to the CCl(4)-injured liver than the normoxic cells. Hypoxic treatment of BMCs may have merits in decreasing apoptosis of those cells as well as in enhancing cellular migration to SDF-1 alpha, the chemokine which binds to BMCs expressed CXCR4 and to the injured tissue, such as CCl(4) damaged liver. (C) 2008 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.ko_KR
dc.language.isoenko_KR
dc.publisherACADEMIC PRESS LTD- ELSEVIER SCIENCE LTDko_KR
dc.subjectBone marrow cellsko_KR
dc.subjectHypoxiako_KR
dc.subjectCell migrationko_KR
dc.subjectSDF-1ko_KR
dc.titleEffect of hypoxic treatment on bone marrow cells that are able to migrate to the injured liverko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor주선영-
dc.contributor.AlternativeAuthor조경아-
dc.contributor.AlternativeAuthor조수진-
dc.contributor.AlternativeAuthor정윤재-
dc.contributor.AlternativeAuthor우소윤-
dc.contributor.AlternativeAuthor서주영-
dc.contributor.AlternativeAuthor한호성-
dc.contributor.AlternativeAuthor류경하-
dc.identifier.doi10.1016/j.cellbi.2008.10.002-
dc.citation.journaltitleCELL BIOLOGY INTERNATIONAL-
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College of Medicine/School of Medicine (의과대학/대학원)Surgery (외과학전공)Journal Papers (저널논문_외과학전공)
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