S-Space College of Medicine/School of Medicine (의과대학/대학원) Biomedical Engineering (의공학전공) Journal Papers (저널논문_의공학전공)
Quantitative Analysis of Pulsatile Flow Contribution to Ultrafiltration
- Lim, Ki Moo; Park, Joong Yull; Lee, Jung Chan; Kim, Jeong Chul; Kang, Eung Taeck; Shim, Eun Bo; Min, Byoung Goo
- Issue Date
- WILEY-BLACKWELL PUBLISHING, INC
- ARTIFICIAL ORGANS; Vol.33 1; 69-73
- Ultrafiltration; Membrane layering; Membrane stretch; Fluid power; Mean transmembrane pressure; Pulsatile pump; Roller pump
- We evaluated the quantitative contribution of pulsatile flow to ultrafiltration (UF) in terms of fluid power, membrane stretch, and reduction of membrane layering. An in vitro comparison of the UF rate using pulsatile and roller pumps was performed with distilled water and bovine whole blood. The mean transmembrane pressure (TMPm) and UF rate were higher with the pulsatile pump for the same mean flow rate: 6.6 mm Hg and 21.1 mL/min higher on average for distilled water and 34.2 mm Hg and 31.4 mL/min higher on average for blood. The average UF rate was 8.4 mL/min higher with the pulsatile pump for the same TMPm with bovine blood. However, the relationship between the UF rate and the TMPm was independent of the flow configuration for distilled water. We showed that the higher UF rate in the pulsatile pump is mainly due to greater fluid power and reduction of membrane layering, while the membrane stretch was not an important factor.
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