S-Space College of Veterinary Medicine (수의과대학) Dept. of Veterinary Medicine (수의학과) Journal Papers (저널논문_수의학과)
Age-related Differentiation in Newly Generated DCX Immunoreactive Neurons in the Subgranular Zone of the Gerbil Dentate Gyrus
- Hwang, In Koo; Yoo, Ki-Yeon; Yi, Sun Shin; Kwon, Young-Guen; Ahn, Young-Keun; Sung, Je Kyeong; Lee, In Se; Yoon, Yeo Sung; Won, Moo-Ho
- Issue Date
- Springer Verlag
- Neurochem Res 33:867-872
- In the present study, we investigated age-related changes of newborn neurons in the gerbil dentate gyrus using doublecortin (DCX), a marker of neuronal progenitors which differentiate into neurons in the brain. In the postnatal month 1 (PM 1) group, DCX immunoreactivity was detected in the subgranular zone of the dentate gyrus, but DCX immunoreactive neurons did not have fully developed processes. Thereafter, DCX immunoreactivity and its protein levels in the dentate gyrus were found to decrease with age. Between PM 3 and PM 18, DCX immunoreactive neuronal progenitors showed well-developed processes which projected to the granular layer of the dentate gyrus, but at PM 24, a few DCX immunoreactive neuronal progenitors were detected in the subgranular zone of the dentate gyrus. DCX protein level in the dentate gyrus at PM 1 was high, thereafter levels of DCX were decreased with time. The authors suggest that a decrease of DCX immunoreactivity and its protein level with age may be associated with aging processes in the hippocampal dentate gyrus.
- 0364-3190 (Print)
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