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Anti-angiogenic effect of caffeic acid on retinal neovascularization

Cited 31 time in Web of Science Cited 36 time in Scopus
Issue Date
2009-10
Publisher
ELSEVIER SCIENCE INC
Citation
VASCULAR PHARMACOLOGY; Vol.51 4; 262-267
Keywords
Anti-angiogenicReactive oxygen speciesVascular endothelial growth factorRetinal neovascularizationAnti-oxidantCaffeic acid
Abstract
Pathological angiogenesis is the most common cause of vision loss at all ages including retinopathy of prematurity (ROP). diabetic retinopathy. and age-related macular degeneration. ROP is a proliferative disease of the retinal vasculature in premature infants. Herein, we demonstrated caffeic acid (CA) has the anti-angiogenic activity to retinal endothelial cells and retinal neovascularization in a mouse model of ROP. which might be related to the suppression of ROS-induced VEGF expression. CA effectively inhibited VEGF-induced proliferation of retinal endothelial cells in concentration-dependent manner. In addition, VEGF-induced migration and tube formation of retinal endothelial cells were completely inhibited This anti-angiogenic activity of CA on retinal endothelial cells was related to the anti-oxidant activity the inhibitory activity of CA to H(2)O(2)-induced reactive oxygen species production and VEGF expression. Interestingly, CA significantly suppressed retinal neovascularization in oxygen-induced retinopathy as the animal model of ROP without retinal cytotoxicity These data suggests that CA could be a potent anti-angiogenic agent for retinal neovascularization, and be applied in the treatment of other vaso-proliferative retinopathies Published by Elsevier Inc.
ISSN
1537-1891
Language
English
URI
https://hdl.handle.net/10371/77952
DOI
https://doi.org/10.1016/j.vph.2009.06.010
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College of Medicine/School of Medicine (의과대학/대학원)Ophthalmology (안과학전공)Journal Papers (저널논문_안과학전공)
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