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Anti-angiogenic effect of caffeic acid on retinal neovascularization
Cited 31 time in
Web of Science
Cited 36 time in Scopus
- Authors
- Issue Date
- 2009-10
- Publisher
- ELSEVIER SCIENCE INC
- Citation
- VASCULAR PHARMACOLOGY; Vol.51 4; 262-267
- Keywords
- Anti-angiogenic ; Reactive oxygen species ; Vascular endothelial growth factor ; Retinal neovascularization ; Anti-oxidant ; Caffeic acid
- Abstract
- Pathological angiogenesis is the most common cause of vision loss at all ages including retinopathy of prematurity (ROP). diabetic retinopathy. and age-related macular degeneration. ROP is a proliferative disease of the retinal vasculature in premature infants. Herein, we demonstrated caffeic acid (CA) has the anti-angiogenic activity to retinal endothelial cells and retinal neovascularization in a mouse model of ROP. which might be related to the suppression of ROS-induced VEGF expression. CA effectively inhibited VEGF-induced proliferation of retinal endothelial cells in concentration-dependent manner. In addition, VEGF-induced migration and tube formation of retinal endothelial cells were completely inhibited This anti-angiogenic activity of CA on retinal endothelial cells was related to the anti-oxidant activity the inhibitory activity of CA to H(2)O(2)-induced reactive oxygen species production and VEGF expression. Interestingly, CA significantly suppressed retinal neovascularization in oxygen-induced retinopathy as the animal model of ROP without retinal cytotoxicity These data suggests that CA could be a potent anti-angiogenic agent for retinal neovascularization, and be applied in the treatment of other vaso-proliferative retinopathies Published by Elsevier Inc.
- ISSN
- 1537-1891
- Language
- English
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