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Anti-angiogenic effect of caffeic acid on retinal neovascularization
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jeong Hun | - |
dc.contributor.author | Lee, Byung Joo | - |
dc.contributor.author | Kim, Jin Hyoung | - |
dc.contributor.author | Yu, Young Suk | - |
dc.contributor.author | Kim, Kyu-Won | - |
dc.date.accessioned | 2012-06-29T05:55:55Z | - |
dc.date.available | 2012-06-29T05:55:55Z | - |
dc.date.issued | 2009-10 | - |
dc.identifier.citation | VASCULAR PHARMACOLOGY; Vol.51 4; 262-267 | ko_KR |
dc.identifier.issn | 1537-1891 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77952 | - |
dc.description.abstract | Pathological angiogenesis is the most common cause of vision loss at all ages including retinopathy of prematurity (ROP). diabetic retinopathy. and age-related macular degeneration. ROP is a proliferative disease of the retinal vasculature in premature infants. Herein, we demonstrated caffeic acid (CA) has the anti-angiogenic activity to retinal endothelial cells and retinal neovascularization in a mouse model of ROP. which might be related to the suppression of ROS-induced VEGF expression. CA effectively inhibited VEGF-induced proliferation of retinal endothelial cells in concentration-dependent manner. In addition, VEGF-induced migration and tube formation of retinal endothelial cells were completely inhibited This anti-angiogenic activity of CA on retinal endothelial cells was related to the anti-oxidant activity the inhibitory activity of CA to H(2)O(2)-induced reactive oxygen species production and VEGF expression. Interestingly, CA significantly suppressed retinal neovascularization in oxygen-induced retinopathy as the animal model of ROP without retinal cytotoxicity These data suggests that CA could be a potent anti-angiogenic agent for retinal neovascularization, and be applied in the treatment of other vaso-proliferative retinopathies Published by Elsevier Inc. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE INC | ko_KR |
dc.subject | Anti-angiogenic | ko_KR |
dc.subject | Reactive oxygen species | ko_KR |
dc.subject | Vascular endothelial growth factor | ko_KR |
dc.subject | Retinal neovascularization | ko_KR |
dc.subject | Anti-oxidant | ko_KR |
dc.subject | Caffeic acid | ko_KR |
dc.title | Anti-angiogenic effect of caffeic acid on retinal neovascularization | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김정훈 | - |
dc.contributor.AlternativeAuthor | 이병주 | - |
dc.contributor.AlternativeAuthor | 김진형 | - |
dc.contributor.AlternativeAuthor | 유영석 | - |
dc.contributor.AlternativeAuthor | 김규원 | - |
dc.identifier.doi | 10.1016/j.vph.2009.06.010 | - |
dc.citation.journaltitle | VASCULAR PHARMACOLOGY | - |
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dc.description.tc | 6 | - |
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