Publications
Detailed Information
The incidence, risk factors and prognostic implications of venous thromboembolism in patients with gastric cancer
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, K. W. | - |
dc.contributor.author | Bang, S. M. | - |
dc.contributor.author | Kim, S. | - |
dc.contributor.author | Lee, H. J. | - |
dc.contributor.author | Koh, Y. | - |
dc.contributor.author | Cha, Y. | - |
dc.contributor.author | Kim, J. H. | - |
dc.contributor.author | Kim, H. H. | - |
dc.contributor.author | Lee, J. S. | - |
dc.contributor.author | Oh, D. | - |
dc.contributor.author | Park, D. J. | - |
dc.contributor.author | Kim, Y. J. | - |
dc.contributor.author | Lee, Y. G. | - |
dc.contributor.author | Shin, D. Y. | - |
dc.date.accessioned | 2012-06-29T06:41:38Z | - |
dc.date.available | 2012-06-29T06:41:38Z | - |
dc.date.issued | 2010-03 | - |
dc.identifier.citation | JOURNAL OF THROMBOSIS AND HAEMOSTASIS; Vol.8 3; 540-547 | ko_KR |
dc.identifier.issn | 1538-7933 | - |
dc.identifier.uri | https://hdl.handle.net/10371/77967 | - |
dc.description.abstract | Background: Data on venous thromboembolism (VTE) in gastric cancer (GC) are very scarce. Objective: To investigate the incidence, risk factors and prognostic implications of VTE in Asian GC patients. Methods: Prospective databases containing clinical information on GC patients (n = 2,085) were used. Results: The 2-year cumulative incidences of all VTE events were 0.5%, 3.5% and 24.4% in stages I, II-IV(M0) and IV(M1), respectively. Advanced stage, older age and no major surgery were independent risk factors for developing VTE. When the VTE cases were classified into extremity venous thrombosis (EVT), pulmonary thromboembolism (PTE) or intra-abdominal venous thrombosis (IVT), IVTs (62%) were more common than EVTs (21%) or PTEs (17%). Although peri-operative pharmacologic thromboprophylaxis was not routinely administered, the VTE incidence after major surgery was only 0.2%. During chemotherapy, EVT/PTE developed more frequently than IVT (54% vs. 19%); however, during untreated or treatment-refractory periods, IVT developed more frequently than EVT/PTE (69% vs. 36%). In multivariate models, the development of EVT/PTE was a significant predictor of early death when compared with no occurrence of VTE (P < 0.05). However, IVT did not affect survival. Conclusion: This is the largest study that specially focused on VTE in GC and the VTE incidence in Asian GC patients was first demonstrated. Considering the low incidence of post-operative VTE development, the necessity of peri-operative pharmacologic thromboprophylaxis should be evaluated separately in Asian patients. The clinical situation of the development of EVT/PTE and IVT differed. Only EVT/PTE had an adverse effect on survival and IVT had no prognostic significance. | ko_KR |
dc.description.sponsorship | This study was partially supported by grants from Seoul
National University Bundang Hospital Research Fund (03- 2009-012).We are grateful to Medical Research Collaborating Center (MRCC) at Seoul National University Hospital for the statistical assistance in the revision of this manuscript. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-BLACKWELL PUBLISHING, INC | ko_KR |
dc.subject | gastric cancer | ko_KR |
dc.subject | venous thromboembolism | ko_KR |
dc.subject | thrombosis | ko_KR |
dc.title | The incidence, risk factors and prognostic implications of venous thromboembolism in patients with gastric cancer | ko_KR |
dc.type | Article | ko_KR |
dc.identifier.doi | 10.1111/j.1538-7836.2009.03731.x | - |
dc.citation.journaltitle | JOURNAL OF THROMBOSIS AND HAEMOSTASIS | - |
dc.description.citedreference | Hwang SH, 2009, J AM COLL SURGEONS, V208, P186, DOI 10.1016/j.jamcollsurg.2008.10.023 | - |
dc.description.citedreference | Martinelli I, 2008, BLOOD, V112, P4818, DOI 10.1182/blood-2008-07-165969 | - |
dc.description.citedreference | PARK JM, 2008, GASTROINTEST CANC RE, V2, P137 | - |
dc.description.citedreference | Oh SY, 2008, THROMB RES, V122, P485, DOI 10.1016/j.thromres.2007.12.015 | - |
dc.description.citedreference | Lyman GH, 2007, J CLIN ONCOL, V25, P5490, DOI 10.1200/JCO.2007.14.1283 | - |
dc.description.citedreference | Tetzlaff ED, 2007, CANCER, V109, P1989, DOI 10.1002/cncr.22626 | - |
dc.description.citedreference | De Stefano V, 2007, J THROMB HAEMOST, V5, P708 | - |
dc.description.citedreference | Chew HK, 2007, J CLIN ONCOL, V25, P70, DOI 10.1200/JCO.2006.07.4393 | - |
dc.description.citedreference | Lee SI, 2006, J AM COLL SURGEONS, V202, P874, DOI 10.1016/j.jamcollsurg.2006.02.028 | - |
dc.description.citedreference | Ohtsu A, 2006, J CLIN ONCOL, V24, P2188 | - |
dc.description.citedreference | Alcalay A, 2006, J CLIN ONCOL, V24, P1112, DOI 10.1200/JCO.2005.04.2150 | - |
dc.description.citedreference | Chew HK, 2006, ARCH INTERN MED, V166, P458 | - |
dc.description.citedreference | Primignani M, 2005, HEPATOLOGY, V41, P603, DOI 10.1002/hep.20591 | - |
dc.description.citedreference | SHIN HR, 2004, CANC RES TREAT, V36, P103 | - |
dc.description.citedreference | LEE AY, 2003, CIRCULATION, V107, P117 | - |
dc.description.citedreference | Madonna P, 2001, GASTROENTEROLOGY, V120, P1059 | - |
dc.description.citedreference | Amitrano L, 2001, AM J GASTROENTEROL, V96, P146 | - |
dc.description.citedreference | Sorensen HT, 2000, NEW ENGL J MED, V343, P1846 | - |
dc.description.citedreference | Janssen HLA, 2000, BLOOD, V96, P2364 | - |
dc.description.citedreference | GOLLIN G, 1994, J CLIN GASTROENTEROL, V18, P109 | - |
dc.description.tc | 7 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.