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Sustained expression of parvalbumin immunoreactivity in the hippocampal CA1 region and dentate gyrus during aging in dogs

Cited 4 time in Web of Science Cited 5 time in Scopus
Authors
Hwang, In Koo; Yoon, Yeo Sung; Yoo, Ki-Yeon; Li, Hua; Sun, Yuanjie; Choi, Jung Hoon; Lee, Choong Hyun; Huh, Sung-Oh; Lee, Yun Lyul; Won, Moo-Ho
Issue Date
2008-01-19
Publisher
Elsevier
Citation
Neurosci. Lett. 434 (2008) 99-103
Keywords
AgingHippocampusParvalbuminImmunohistochemistryDog
Abstract
The hippocampus contains a heterogeneous population of interneurons. Parvalbumin (PV) positive neurons constitute an abundant subpopulation of cells that express GABA. The authors observed PV immunoreactivity in the hippocampal CA1 region and dentate gyrus of variously aged dogs. In 1-year-old dogs, PV immunoreactive neurons were detected in the stratum oriens of the CA1 region, and in the polymorphic layer of the dentate gyrus. In addition, weak PV immunoreactive fibers were observed in all layers in the CA1 region and dentate gyrus. In 3-year-old dogs, PV immunoreactivity was significantly higher in the CA1 region and dentate gyrus, and this was maintained in 10-year-old dogs. This finding suggests that PV immunoreactive interneurons may show high resistance to age-dependent neurodegenerative processes.
ISSN
0304-3940
Language
English
URI
http://hdl.handle.net/10371/7800
DOI
https://doi.org/10.1016/j.neulet.2008.01.035
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College of Veterinary Medicine (수의과대학)Dept. of Veterinary Medicine (수의학과)Journal Papers (저널논문_수의학과)
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