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Neurotrophin Receptors TrkA and TrkB in Retinoblastoma Are Differentially Expressed Depending on Cellular Differentiation
DC Field | Value | Language |
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dc.contributor.author | Kim, Jeong Hun | - |
dc.contributor.author | Kim, Jin Hyoung | - |
dc.contributor.author | Kim, Dong Hun | - |
dc.contributor.author | Cho, Chang Sik | - |
dc.contributor.author | Yu, Young Suk | - |
dc.contributor.author | Kim, Kyu-Won | - |
dc.contributor.author | Jun, Hyoung-Oh | - |
dc.date.accessioned | 2012-06-29T08:59:36Z | - |
dc.date.available | 2012-06-29T08:59:36Z | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | TUMOR BIOLOGY; Vol.30 ; 233-241 | ko_KR |
dc.identifier.issn | 1010-4283 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78000 | - |
dc.description.abstract | Retinoblastoma is the most common primary intraocular malignancy in children. With the progression of retinoblastoma, retinoblastoma cells lose their ability to differentiate. Regardless of many attempts to identify prognostic factors in retinoblastoma, further investigation for prognostic factors of retinoblastoma progression is still required because of the lack of sensitivity and specificity of these prognostic factors in predicting disease progression. We demonstrated that the differential expression of the neurotrophin receptors TrkA and TrkB is closely related to the differentiation of retinoblastoma cells. While retinoblastoma cells expressed TrkA as well as TrkB, their growth rates were not influenced by the addition of nerve growth factor to the culture medium. In experimental animal models of retinoblastoma, TrkA expression was primarily detected in more differentiated areas with high nm23 immunoreactivity whereas TrkB expression was apparent in more proliferative areas with high Ki67 immunoreactivity. With retinoic-acid-induced differentiation of retinoblastoma cells, TrkA expression significantly increased whereas TrkB significantly decreased. The differential expression of TrkA and TrkB with differentiation of retinoblastoma cells was mediated by extracellular-signal-regulated kinase 1/2 activation, which was confirmed by immunocytochemistry of TrkA. Therefore, our results suggest that the differential expression of TrkA and TrkB could be valuable as a therapeutic target, for instance using specific inhibitors. Copyright (C) 2009 S. Karger AG, Basel | ko_KR |
dc.description.sponsorship | This study was supported by a grant from the National R&D
program for cancer control, Ministry of Health & Welfare, Republic of Korea (800-20090246) and grant No. 04-2008-050 from the Seoul National University Hospital Research. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | KARGER | ko_KR |
dc.subject | Differentiation | ko_KR |
dc.subject | TrkB | ko_KR |
dc.subject | Extracellular signal-regulated kinase | ko_KR |
dc.subject | Retinoblastoma | ko_KR |
dc.subject | TrkA | ko_KR |
dc.title | Neurotrophin Receptors TrkA and TrkB in Retinoblastoma Are Differentially Expressed Depending on Cellular Differentiation | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김정훈 | - |
dc.contributor.AlternativeAuthor | 김진형 | - |
dc.contributor.AlternativeAuthor | 김동헌 | - |
dc.contributor.AlternativeAuthor | 조창식 | - |
dc.contributor.AlternativeAuthor | 전형오 | - |
dc.contributor.AlternativeAuthor | 유영석 | - |
dc.contributor.AlternativeAuthor | 김규원 | - |
dc.identifier.doi | 10.1159/000243766 | - |
dc.citation.journaltitle | TUMOR BIOLOGY | - |
dc.description.citedreference | Kim JH, 2008, HUM PATHOL, V39, P1172, DOI 10.1016/j.humpath.2007.12.008 | - |
dc.description.citedreference | Stephan H, 2008, PEDIATR BLOOD CANCER, V50, P218, DOI 10.1002/pbc.21369 | - |
dc.description.citedreference | Kim JH, 2007, ONCOL REP, V18, P1373 | - |
dc.description.citedreference | Kampmann E, 2007, NEUROSCI LETT, V426, P18, DOI 10.1016/j.neulet.2007.07.039 | - |
dc.description.citedreference | Kim JH, 2007, INT J ONCOL, V31, P585 | - |
dc.description.citedreference | Johnson DA, 2007, CANCER RES, V67, P2701, DOI 10.1158/0008-5472.CAN-06-3754 | - |
dc.description.citedreference | Laurie NA, 2006, NATURE, V444, P61, DOI 10.1038/nature05194 | - |
dc.description.citedreference | Kruttgen A, 2006, BRAIN PATHOL, V16, P304 | - |
dc.description.citedreference | Clagett-Dame M, 2006, J NEUROBIOL, V66, P739, DOI 10.1002/neu.20241 | - |
dc.description.citedreference | Chen D, 2004, CANCER CELL, V5, P539 | - |
dc.description.citedreference | Lachyankar MB, 2003, J NEUROSCI RES, V71, P157, DOI 10.1002/jnr.10480 | - |
dc.description.citedreference | Ho R, 2002, CANCER RES, V62, P6462 | - |
dc.description.citedreference | Lillington DM, 2002, BRIT J CANCER, V87, P779, DOI 10.1038/sj.bjc.6600532 | - |
dc.description.citedreference | Wagner N, 2000, INVEST OPHTH VIS SCI, V41, P1932 | - |
dc.description.citedreference | Eggert A, 2000, ONCOGENE, V19, P2043 | - |
dc.description.citedreference | Nag TC, 1999, DEV BRAIN RES, V117, P179 | - |
dc.description.citedreference | Kimura N, 1996, ENDOCR PATHOL, V7, P281 | - |
dc.description.citedreference | Khelfaoui F, 1996, CANCER, V77, P1206 | - |
dc.description.citedreference | HOEHNER JC, 1995, AM J PATHOL, V147, P102 | - |
dc.description.citedreference | LAVENIUS E, 1995, CELL GROWTH DIFFER, V6, P727 | - |
dc.description.citedreference | MATSUMOTO K, 1995, CANCER RES, V55, P1798 | - |
dc.description.citedreference | BARBACID M, 1995, CURR OPIN CELL BIOL, V7, P148 | - |
dc.description.citedreference | VERDI JM, 1994, NEURON, V12, P733 | - |
dc.description.citedreference | SHIELDS CL, 1994, CANCER, V73, P692 | - |
dc.description.citedreference | SHIELDS CL, 1993, BRIT J OPHTHALMOL, V77, P544 | - |
dc.description.citedreference | NAKAGAWARA A, 1993, NEW ENGL J MED, V328, P847 | - |
dc.description.citedreference | KOPELMAN JE, 1987, OPHTHALMOLOGY, V94, P371 | - |
dc.description.citedreference | SQUIRE J, 1986, NATURE, V322, P555 | - |
dc.description.citedreference | LEE WH, 1984, NATURE, V309, P458 | - |
dc.description.citedreference | KNUDSON AG, 1971, P NATL ACAD SCI USA, V68, P820 | - |
dc.description.tc | 0 | - |
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