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The Anti-inflammatory Effect of Subconjunctival Bevacizumab on Chemically Burned Rat Corneas

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dc.contributor.authorOh, Joo Youn-
dc.contributor.authorKim, Mee Kum-
dc.contributor.authorShin, Mi Sun-
dc.contributor.authorLee, Hyun Ju-
dc.contributor.authorWee, Won Ryang-
dc.contributor.authorLee, Jin Hak-
dc.date.accessioned2012-07-02T02:05:41Z-
dc.date.available2012-07-02T02:05:41Z-
dc.date.issued2009-
dc.identifier.citationCURRENT EYE RESEARCH; Vol.34 2; 85-91ko_KR
dc.identifier.issn0271-3683-
dc.identifier.urihttps://hdl.handle.net/10371/78052-
dc.description.abstractPurpose: To investigate the effect of bevacizumab in a model of corneal inflammation. Materials and Methods: Epithelium from the cornea and limbus was completely removed using 100% alcohol in rats. Bevacizumab (1.25 mg/0.05 ml) or normal saline was subconjunctivally injected. One week later, corneas were examined and subjected to hematoxylin-eosin and immunofluorescent staining for VEGF. Expression of IL-2, IFN-, IL-6, and TGF- 1 were analyzed by ELISA. Results: Bevacizumab showed a borderline reduction in corneal neovascularization (11.0 4.8% and 18.0 10.0% in the bevacizumab and control groups, respectively; p = 0.054), while the extent of epithelialization was not affected (5.0 3.4% and 6.1 5.2% in the bevacizumab and control groups, respectively; p = 0.715). The infiltration of inflammatory cells was reduced (99.3 22.3 cells/ 400 in the bevacizumab-injected corneas and 182.3 58.0 cells/ 400 in the controls; p = 0.013). The levels of IL-2, IFN-, and IL-6 were decreased in the rats with the bevacizumab injections (44 6 and 79 9 pg/ml for IL-2 in the bevacizumab-injected group and control, respectively, p = 0.025; 45 5 and 67 6 pg/ml for IFN- in the bevacizumab-injected group and controls, respectively, p = 0.043; 45 6 and 75 8 pg/ml for IL-6 in the bevacizumab-injected group and controls, respectively, p = 0.030). Conclusions: Bavacizumab showed a reduction in inflammatory cell infiltration and cytokines in chemically burned rat corneas.ko_KR
dc.language.isoenko_KR
dc.publisherINFORMA HEALTHCAREko_KR
dc.subjectangiogenesisko_KR
dc.subjectinflammationko_KR
dc.subjectepitheliumko_KR
dc.subjectbevacizumabko_KR
dc.subjectcorneako_KR
dc.titleThe Anti-inflammatory Effect of Subconjunctival Bevacizumab on Chemically Burned Rat Corneasko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor오주윤-
dc.contributor.AlternativeAuthor김미금-
dc.contributor.AlternativeAuthor신미선-
dc.contributor.AlternativeAuthor이현주-
dc.contributor.AlternativeAuthor이진학-
dc.contributor.AlternativeAuthor위원량-
dc.identifier.doi10.1080/02713680802607740-
dc.citation.journaltitleCURRENT EYE RESEARCH-
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dc.description.tc11-
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