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Gold nanoparticles attenuate LPS-induced NO production through the inhibition of NF-kappa B and IFN-beta/STAT1 pathways in RAW264.7 cells

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dc.contributor.authorMa, Ji Su-
dc.contributor.authorKim, Wan Jae-
dc.contributor.authorKim, Jae Jin-
dc.contributor.authorKim, Tack Joong-
dc.contributor.authorSong, Min Dong-
dc.contributor.authorKim, Dong Woo-
dc.contributor.authorLee, Kwang Ho-
dc.contributor.authorMoon, Won Kook-
dc.contributor.authorKang, Hyun-
dc.contributor.authorYe, Sang Kyu-
dc.date.accessioned2012-07-02T04:31:59Z-
dc.date.available2012-07-02T04:31:59Z-
dc.date.issued2010-11-01-
dc.identifier.citationNITRIC OXIDE-BIOLOGY AND CHEMISTRY; Vol.23 3; 214-219ko_KR
dc.identifier.issn1089-8603-
dc.identifier.urihttps://hdl.handle.net/10371/78067-
dc.description.abstractMacrophage-derived nitric oxide (NO) plays an important role in protection against microbial infection in immune responses. Overproduction of NO by inducible nitric synthase (iNOS) is known to be closely correlated with the pathology of a variety of diseases and inflammations. In this study, we investigated the inhibitory effect of polyethylene glycol coated gold nanoparticles (GNP) on NO production and its molecular mechanism in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. It was found that GNP inhibited LPS-induced NO production and iNOS expression in RAW264.7 cells. Furthermore, GNP suppressed LPS-induced activation of NF-kappa B through the inhibition of Akt activity. GNP also inhibited LPS-induced phosphorylation of signal transducer and activator of transcription 1 (STAT1) via down-regulation of interferon-beta (IFN-beta) expression. Our results suggest that GNP inhibits NO production and iNOS expression through blocking the activation of NF-kappa B and STAT1 in LPS-stimulated RAW264.7 cells. (C) 2010 Elsevier Inc. All rights reserved.ko_KR
dc.language.isoenko_KR
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEko_KR
dc.subjectGold nanoparticlesko_KR
dc.subjectInterferon-beta (IFN-beta)ko_KR
dc.subjectInducible nitric synthase (iNOS)ko_KR
dc.subjectNitric oxide (NO)ko_KR
dc.subjectSignal transducer and activator of transcription 1 (STAT1)ko_KR
dc.subjectLipopolysaccharide (LPS)ko_KR
dc.titleGold nanoparticles attenuate LPS-induced NO production through the inhibition of NF-kappa B and IFN-beta/STAT1 pathways in RAW264.7 cellsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor마지수-
dc.contributor.AlternativeAuthor김완재-
dc.contributor.AlternativeAuthor김재진-
dc.contributor.AlternativeAuthor김탁중-
dc.contributor.AlternativeAuthor예상규-
dc.contributor.AlternativeAuthor송민동-
dc.contributor.AlternativeAuthor강현-
dc.contributor.AlternativeAuthor김동우-
dc.contributor.AlternativeAuthor문원국-
dc.contributor.AlternativeAuthor이광호-
dc.identifier.doi10.1016/j.niox.2010.06.005-
dc.citation.journaltitleNITRIC OXIDE-BIOLOGY AND CHEMISTRY-
dc.description.citedreferenceYen HJ, 2009, SMALL, V5, P1553, DOI 10.1002/smll.200900126-
dc.description.citedreferenceNiethammer P, 2009, NATURE, V459, P996, DOI 10.1038/nature08119-
dc.description.citedreferenceOUTI S, 2008, INT IMMUNOPHARMACOL, V8, P100-
dc.description.citedreferenceJung CH, 2007, J ETHNOPHARMACOL, V113, P183, DOI 10.1016/j.jep.2007.05.023-
dc.description.citedreferenceHsu SH, 2006, J BIOMED MATER RES A, V79A, P759, DOI 10.1002/bm.a.30879-
dc.description.citedreferenceLim YT, 2006, ADV FUNCT MATER, V16, P1015, DOI 10.1002/adfm.200500860-
dc.description.citedreferenceAkira S, 2006, CELL, V124, P783, DOI 10.1016/j.cell.2006.02.015-
dc.description.citedreferenceShukla R, 2005, LANGMUIR, V21, P10644, DOI 10.1021/la0513712-
dc.description.citedreferenceFortina P, 2005, TRENDS BIOTECHNOL, V23, P168, DOI 10.1016/j.tibtech.2005.02.007-
dc.description.citedreferenceDeonarain R, 2004, CIRCULATION, V110, P3540, DOI 10.1161/01.CIR.0000136824.73458.20-
dc.description.citedreferenceAkira S, 2004, NAT REV IMMUNOL, V4, P499, DOI 10.1038/nri1391-
dc.description.citedreferenceHattori Y, 2003, EUR J PHARMACOL, V481, P153, DOI 10.1016/j.ejphar.2003.09.034-
dc.description.citedreferenceDuffield JS, 2003, CLIN SCI, V104, P27-
dc.description.citedreferenceMARINA K, 2003, NAT IMMUNOL, V4, P471-
dc.description.citedreferenceSwindle EJ, 2002, J IMMUNOL, V169, P5866-
dc.description.citedreferenceChang H, 2002, CAN J ANAESTH, V49, P477-
dc.description.citedreferenceToshchakov V, 2002, NAT IMMUNOL, V3, P392, DOI 10.1038/ni774-
dc.description.citedreferenceKawai T, 2001, J IMMUNOL, V167, P5887-
dc.description.citedreferenceChung HT, 2001, BIOCHEM BIOPH RES CO, V282, P1075-
dc.description.citedreferenceOhmori Y, 2001, J LEUKOCYTE BIOL, V69, P598-
dc.description.citedreferenceChan ED, 2001, AM J PHYSIOL-CELL PH, V280, pC441-
dc.description.citedreferenceGuha M, 2001, CELL SIGNAL, V13, P85-
dc.description.citedreferenceDetmers PA, 2000, J IMMUNOL, V165, P3430-
dc.description.citedreferenceJeon YJ, 2000, J PHARMACOL EXP THER, V294, P548-
dc.description.citedreferencePan MH, 2000, BIOCHEM PHARMACOL, V59, P357-
dc.description.citedreferenceGuan ZH, 1999, J BIOL CHEM, V274, P36200-
dc.description.citedreferenceKarin M, 1999, J BIOL CHEM, V274, P27339-
dc.description.citedreferenceHobbs AJ, 1999, ANNU REV PHARMACOL, V39, P191-
dc.description.citedreferenceGao JJ, 1998, J IMMUNOL, V161, P4803-
dc.description.citedreferenceGhosh S, 1998, ANNU REV IMMUNOL, V16, P225-
dc.description.citedreferenceMacMicking J, 1997, ANNU REV IMMUNOL, V15, P323-
dc.description.citedreferenceBaeuerle PA, 1997, ADV IMMUNOL, V65, P111-
dc.description.citedreferenceLIU RH, 1995, MUTAT RES-REV GENET, V339, P73-
dc.description.citedreferenceMULLER U, 1994, SCIENCE, V264, P1918-
dc.description.citedreferenceXIE QW, 1994, J BIOL CHEM, V269, P4705-
dc.description.citedreferenceMARIETTA MA, 1993, J BIOL CHEM, V268, P12231-
dc.description.citedreferenceNATHAN C, 1992, FASEB J, V6, P3051-
dc.description.citedreferenceXIE QW, 1992, SCIENCE, V256, P228-
dc.description.citedreferencePETROS A, 1991, LANCET, V338, P1557-
dc.description.citedreferenceMONCADA S, 1991, PHARMACOL REV, V43, P109-
dc.description.citedreferenceADAMS DO, 1984, ANNU REV IMMUNOL, V2, P283-
dc.description.tc5-
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College of Medicine/School of Medicine (의과대학/대학원)Pharmacology (약리학전공)Journal Papers (저널논문_약리학전공)
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