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Crystal Structure of the N-terminal Domain of Anaphase-promoting Complex Subunit 7
DC Field | Value | Language |
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dc.contributor.author | Han, Dohyun | - |
dc.contributor.author | Kim, Kyunggon | - |
dc.contributor.author | Kim, Yeonjung | - |
dc.contributor.author | Kang, Yup | - |
dc.contributor.author | Kim, Youngsoo | - |
dc.contributor.author | Lee, Ji Yoon | - |
dc.date.accessioned | 2012-07-03T01:24:06Z | - |
dc.date.available | 2012-07-03T01:24:06Z | - |
dc.date.issued | 2009-05-29 | - |
dc.identifier.citation | JOURNAL OF BIOLOGICAL CHEMISTRY; Vol.284 22; 15137-15146 | ko_KR |
dc.identifier.issn | 0021-9258 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78173 | - |
dc.description.abstract | Anaphase-promoting complex or cyclosome (APC/C) is an unusual E3 ubiquitin ligase and an essential protein that controls mitotic progression. APC/C includes at least 13 subunits, but no structure has been determined for any tetratricopeptide repeat (TPR)-containing subunit (Apc3 and -6-8) in the TPR subcomplex of APC/C. Apc7 is a TPR-containing subunit that exists only in vertebrate APC/C. Here we report the crystal structure of quad mutant of nApc7 (N-terminal fragment, residues 1-147) of human Apc7 at a resolution of 2.5 angstrom. The structure of nApc7 adopts a TPR-like motif and has a unique dimerization interface, although the protein does not contain the conserved TPR sequence. Based on the structure of nApc7, in addition to previous experimental findings, we proposed a putative homodimeric structure for full-length Apc7. This model suggests that TPR-containing subunits self-associate and bind to adaptors and substrates via an IR peptide in TPR-containing subunits of APC/C. | ko_KR |
dc.description.sponsorship | This work was supported by the 21C Frontier Functional Proteomics Project
of the Korean Ministry of Science and Technology Grant FPR 08-A2-110 and by the Innovative Research Institute for Cell Therapy, Republic of Korea, Grant A062260. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC | ko_KR |
dc.title | Crystal Structure of the N-terminal Domain of Anaphase-promoting Complex Subunit 7 | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 한도현 | - |
dc.contributor.AlternativeAuthor | 김경곤 | - |
dc.contributor.AlternativeAuthor | 김연정 | - |
dc.contributor.AlternativeAuthor | 강엽 | - |
dc.contributor.AlternativeAuthor | 이지윤 | - |
dc.contributor.AlternativeAuthor | 김영수 | - |
dc.identifier.doi | 10.1074/jbc.M804887200 | - |
dc.citation.journaltitle | JOURNAL OF BIOLOGICAL CHEMISTRY | - |
dc.description.citedreference | Holm L, 2008, BIOINFORMATICS, V24, P2780, DOI 10.1093/bioinformatics/btn507 | - |
dc.description.citedreference | Han D, 2008, PROTEINS, V70, P900, DOI 10.1002/prot.21597 | - |
dc.description.citedreference | Ohi MD, 2007, MOL CELL, V28, P871, DOI 10.1016/j.molcel.2007.10.003 | - |
dc.description.citedreference | Nyarko A, 2007, BIOCHEMISTRY-US, V46, P11331, DOI 10.1021/bi700735t | - |
dc.description.citedreference | Krissinel E, 2007, J MOL BIOL, V372, P774, DOI 10.1016/j.jmb.2007.05.022 | - |
dc.description.citedreference | Pal M, 2007, J CELL SCI, V120, P3238, DOI 10.1242/jcs.004762 | - |
dc.description.citedreference | Thornton BR, 2006, GENE DEV, V20, P3069, DOI 10.1101/gad.1478306 | - |
dc.description.citedreference | Peters JM, 2006, NAT REV MOL CELL BIO, V7, P644, DOI 10.1038/nrm1988 | - |
dc.description.citedreference | Wu YK, 2006, NAT STRUCT MOL BIOL, V13, P589, DOI 10.1038/nsmb1106 | - |
dc.description.citedreference | Hayes MJ, 2006, NAT CELL BIOL, V8, P607, DOI 10.1038/ncb1410 | - |
dc.description.citedreference | Painter J, 2006, ACTA CRYSTALLOGR D, V62, P439, DOI 10.1107/S0907444906005270 | - |
dc.description.citedreference | Thornton BR, 2006, GENE DEV, V20, P449, DOI 10.1101/gad.1396906 | - |
dc.description.citedreference | Eytan E, 2006, P NATL ACAD SCI USA, V103, P2081, DOI 10.1073/pnas.0510695103 | - |
dc.description.citedreference | Tanaka T, 2006, BIOPOLYMERS, V84, P161, DOI 10.1002/hip.20361 | - |
dc.description.citedreference | Passmore LA, 2005, MOL CELL, V20, P855, DOI 10.1016/j.molcel.2005.11.003 | - |
dc.description.citedreference | Dube P, 2005, MOL CELL, V20, P867, DOI 10.1016/j.molcel.2005.11.008 | - |
dc.description.citedreference | Turnell AS, 2005, NATURE, V438, P690, DOI 10.1038/nature04151 | - |
dc.description.citedreference | Kraft C, 2005, MOL CELL, V18, P543, DOI 10.1016/j.molcel.2005.04.023 | - |
dc.description.citedreference | Wilson CGM, 2005, FEBS J, V272, P166, DOI 10.1111/j.1432-1033.2004.04397.x | - |
dc.description.citedreference | Park KH, 2005, BREAST CANCER RES, V7, pR238, DOI 10.1186/bcr978 | - |
dc.description.citedreference | Emsley P, 2004, ACTA CRYSTALLOGR D, V60, P2126, DOI 10.1107/S0907444904019158 | - |
dc.description.citedreference | Krissinel E, 2004, ACTA CRYSTALLOGR D, V60, P2256, DOI 10.1107/S0907444904026460 | - |
dc.description.citedreference | van Roessel P, 2004, CELL, V119, P707, DOI 10.1016/j.cell.2004.11.028 | - |
dc.description.citedreference | Jinek M, 2004, NAT STRUCT MOL BIOL, V11, P1001, DOI 10.1038/nsmb833 | - |
dc.description.citedreference | Passmore LA, 2004, BIOCHEM J, V379, P513, DOI 10.1042/BJ20040198 | - |
dc.description.citedreference | Konishi Y, 2004, SCIENCE, V303, P1026, DOI 10.1126/science.1093712 | - |
dc.description.citedreference | Terwilliger T, 2004, J SYNCHROTRON RADIAT, V11, P49, DOI 10.1107/S0909049503023938 | - |
dc.description.citedreference | Kraft C, 2003, EMBO J, V22, P6598, DOI 10.1093/emboj/cdg627 | - |
dc.description.citedreference | Gonzalez A, 2003, ACTA CRYSTALLOGR D, V59, P1935, DOI 10.1107/S0907444903017700 | - |
dc.description.citedreference | Vodermaier HC, 2003, CURR BIOL, V13, P1459, DOI 10.1016/S0960-9822(03)00581-5 | - |
dc.description.citedreference | Main ERG, 2003, STRUCTURE, V11, P497, DOI 10.1016/S0969-2126(03)00076-5 | - |
dc.description.citedreference | Terwilliger TC, 2003, METHOD ENZYMOL, V374, P22, DOI 10.1016/S0076-6879(03)74002-6 | - |
dc.description.citedreference | Yoon HJ, 2002, CURR BIOL, V12, P2048, DOI 10.1016/S0960-9822(02)01331-3 | - |
dc.description.citedreference | Winn MD, 2002, ACTA CRYSTALLOGR D, V58, P1929, DOI 10.1107/S0907444902016116 | - |
dc.description.citedreference | Harper JW, 2002, GENE DEV, V16, P2179, DOI 10.1101/gad.1013102 | - |
dc.description.citedreference | Peters JM, 2002, MOL CELL, V9, P931, DOI 10.1016/S1097-2765(02)00540-3 | - |
dc.description.citedreference | Gieffers C, 2001, MOL CELL, V7, P907, DOI 10.1016/S1097-2765(01)00234-9 | - |
dc.description.citedreference | Winn MD, 2001, ACTA CRYSTALLOGR D, V57, P122, DOI 10.1107/S0907444900014736 | - |
dc.description.citedreference | Pfleger CM, 2000, GENE DEV, V14, P655 | - |
dc.description.citedreference | Visintin R, 1997, SCIENCE, V278, P460, DOI 10.1126/science.278.5337.460 | - |
dc.description.citedreference | Garnier J, 1996, METHOD ENZYMOL, V266, P540 | - |
dc.description.citedreference | THOMPSON JD, 1994, NUCLEIC ACIDS RES, V22, P4673, DOI 10.1093/nar/22.22.4673 | - |
dc.description.citedreference | LAMB JR, 1994, EMBO J, V13, P4321 | - |
dc.description.citedreference | JONES TA, 1991, ACTA CRYSTALLOGR A, V47, P110, DOI 10.1107/S0108767390010224 | - |
dc.description.citedreference | GLOTZER M, 1991, NATURE, V349, P132, DOI 10.1038/349132a0 | - |
dc.description.citedreference | MATTHEWS BW, 1968, J MOL BIOL, V33, P491, DOI 10.1016/0022-2836(68)90205-2 | - |
dc.description.tc | 8 | - |
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