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The failure of mitochondria leads to neurodegeneration: Do mitochondria need a jump start?

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dc.contributor.authorLee, Junghee-
dc.contributor.authorJung, Hyun Boo-
dc.contributor.authorRyu, Hoon-
dc.date.accessioned2012-07-03T02:28:23Z-
dc.date.available2012-07-03T02:28:23Z-
dc.date.issued2009-11-30-
dc.identifier.citationADVANCED DRUG DELIVERY REVIEWS; Vol.61 14; 1316-1323ko_KR
dc.identifier.issn0169-409X-
dc.identifier.urihttps://hdl.handle.net/10371/78197-
dc.description.abstractMitochondria are the power engine generating biochemical energy in the cell. Mitochondrial dysfunction and bioenergy deficiency is closely linked to the pathogenesis of neurodegenerative disorders. Mitochondria play a variety of roles by integrating extracellular signals and executing important intracellular events in neuronal survival and death. in this context, the regulation of mitochondrial function via therapeutic approaches may exert some salutary and neuroprotective mechanisms. Understanding the relationship of mitochondria-dependent pathogenesis may provide important pharmacological utility in the treatment of neurodegenerative conditions such as Alzheimer`s disease, amyotrophic lateral sclerosis, Huntington`s disease and Parkinson`s disease. Indeed, the modulation of mitochondrial pathways is rapidly emerging as a novel therapeutic target. This review focuses on how mitochondria are involved in neurodegeneration and what therapeutics are available to target mitochondrial pathways. (C) 2009 Elsevier B.V. All rights reserved.ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER SCIENCE BVko_KR
dc.subjectNeuroprotectionko_KR
dc.subjectAlzheimer`s diseaseko_KR
dc.subjectParkinson`s diseaseko_KR
dc.subjectTherapeuticsko_KR
dc.subjectHuntington`s diseaseko_KR
dc.subjectAmyotrophic lateral sclerosisko_KR
dc.titleThe failure of mitochondria leads to neurodegeneration: Do mitochondria need a jump start?ko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이정희-
dc.contributor.AlternativeAuthor정현부-
dc.contributor.AlternativeAuthor류훈-
dc.identifier.doi10.1016/j.addr.2009.07.016-
dc.citation.journaltitleADVANCED DRUG DELIVERY REVIEWS-
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