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Long-term suppression of tyrosinase by terrein via tyrosinase degradation and its decreased expression

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dc.contributor.authorPark, Seo-Hyoung-
dc.contributor.authorKim, Dong-Seok-
dc.contributor.authorLee, Hyun-Kyung-
dc.contributor.authorKwon, Sun-Bang-
dc.contributor.authorRyoo, In-Ja-
dc.contributor.authorYoo, Ick-Dong-
dc.contributor.authorPark, Kyoung-Chan-
dc.contributor.authorKim, Won-Gon-
dc.contributor.authorLee, Sangku-
dc.date.accessioned2012-07-03T04:49:54Z-
dc.date.available2012-07-03T04:49:54Z-
dc.date.issued2009-06-
dc.identifier.citationEXPERIMENTAL DERMATOLOGY; Vol.18(6); 562-566ko_KR
dc.identifier.issn0906-6705-
dc.identifier.urihttps://hdl.handle.net/10371/78217-
dc.description.abstractPreviously, we reported that a fungal metabolite, terrein, decreases melanin synthesis via downregulation of microphthalmia-associated transcription factor (MITF). In the present study, we further investigated the long-term hypopigmenting action of terrein in a spontaneously immortalized mouse melanocyte cell line, Mel-Ab. Treatment with terrein at a concentration of 50 mu m strongly decreased melanogenesis in a time-dependent manner. Interestingly, the decreased tyrosinase protein levels lasted for at least 7 days, even though the MITF protein levels were restored after 3 days of treatment. In accordance with the results of Western blot analyses, the tyrosinase mRNA levels were found to be continuously decreased for at least 7 days, even though recovery of the MITF mRNA levels began after 3 days of terrein treatment. Therefore, we evaluated tyrosinase downregulation to determine if it is caused by proteasomal degradation. We found that the reduction in tyrosinase levels that was induced by terrein was clearly recovered by MG-132, a proteasome inhibitor. Moreover, ubiquitination of tyrosinase increased following treatment with terrein in the presence of MG-132. Taken together, these results suggest that terrein decreases melanogenesis through ubiquitin-dependent proteasomal degradation as well as via decreased expression of its mRNA.ko_KR
dc.language.isoenko_KR
dc.publisherWILEY-BLACKWELL PUBLISHING, INCko_KR
dc.subjectmelanocyteko_KR
dc.subjectmelanogenesisko_KR
dc.subjecttyrosinaseko_KR
dc.subjectterreinko_KR
dc.subjectproteasomal degradationko_KR
dc.titleLong-term suppression of tyrosinase by terrein via tyrosinase degradation and its decreased expressionko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor박서형-
dc.contributor.AlternativeAuthor김동석-
dc.contributor.AlternativeAuthor이현경-
dc.contributor.AlternativeAuthor권선방-
dc.contributor.AlternativeAuthor이상구-
dc.contributor.AlternativeAuthor류인자-
dc.contributor.AlternativeAuthor김원곤-
dc.contributor.AlternativeAuthor유익동-
dc.contributor.AlternativeAuthor박경찬-
dc.identifier.doi10.1111/j.1600-0625.2009.00847.x-
dc.citation.journaltitleEXPERIMENTAL DERMATOLOGY-
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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