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AVS-1357 inhibits melanogenesis via prolonged ERK activation
DC Field | Value | Language |
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dc.contributor.author | Kim, Dong-Seok | - |
dc.contributor.author | Lee, Hyun-Kyung | - |
dc.contributor.author | Park, Seo-Hyoung | - |
dc.contributor.author | Chae, Chong Hak | - |
dc.contributor.author | Park, Kyoung-Chan | - |
dc.date.accessioned | 2012-07-03T05:51:05Z | - |
dc.date.available | 2012-07-03T05:51:05Z | - |
dc.date.issued | 2009-08 | - |
dc.identifier.citation | PHARMAZIE; Vol.64, no,8; 532-537 | ko_KR |
dc.identifier.issn | 0031-7144 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78261 | - |
dc.description.abstract | In this study, we demonstrated that a derivative of imidazole, AVS-1357, is a novel skin-whitening compound. AVS-1357 was found to significantly inhibit melanin production in a dose-dependent manner; however, it did not directly inhibit tyrosinase. Furthermore, we found that AVS-1357 induced prolonged activation of extracellular signal-regulated kinase (ERK) and Akt, while it downregulated microphthalmia-associated transcription factor (MITF) and tyrosinase. It has been reported that the activation of ERK and/or Akt is involved in melanogenesis. Therefore, we examined the effects of AVS-1357 on melanogenesis in the absence or presence of PD98059 (a specific inhibitor of the ERK pathway) and/or LY294002 (a specific inhibitor of the Akt pathway). PD98059 dramatically increased melanogenesis, whereas LY294002 had no effect. Furthermore, PD98059 attenuated AVS-1357 induced ERK activation, as well as the downregulation of MITF and tyrosinase. These findings suggest that the effects of AVS-1357 occur via downregulation of MITF and tyrosinase, which is caused by AVS-1357-induced prolonged ERK activation. Taken together, our results indicate that AVS-1357 has the potential as a new skin whitening agent. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH | ko_KR |
dc.title | AVS-1357 inhibits melanogenesis via prolonged ERK activation | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 김동석 | - |
dc.contributor.AlternativeAuthor | 이현경 | - |
dc.contributor.AlternativeAuthor | 박서형 | - |
dc.contributor.AlternativeAuthor | 채종학 | - |
dc.contributor.AlternativeAuthor | 박경찬 | - |
dc.identifier.doi | 10.1691/ph.2009.9507 | - |
dc.citation.journaltitle | PHARMAZIE | - |
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