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Reproducibility of the kinetic analysis of 3 `-deoxy-3 `-[(18)F] fluorothymidine positron emission tomography in mouse tumor models
DC Field | Value | Language |
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dc.contributor.author | Choi, Seung Jin | - |
dc.contributor.author | Kim, Seog Young | - |
dc.contributor.author | Kim, Su Jin | - |
dc.contributor.author | Lee, Jae Sung | - |
dc.contributor.author | Park, Soo Ah | - |
dc.contributor.author | Yun, Sung-Cheol | - |
dc.contributor.author | Oh, Seung Jun | - |
dc.contributor.author | Kim, Jae Seung | - |
dc.contributor.author | Moon, Dae Hyuk | - |
dc.contributor.author | Ryu, Jin Sook | - |
dc.contributor.author | Kim, Sang-We | - |
dc.contributor.author | Im, Ki Chun | - |
dc.contributor.author | Lee, Seung Jin | - |
dc.contributor.author | Lee, Sang Ju | - |
dc.date.accessioned | 2012-07-03T07:16:28Z | - |
dc.date.available | 2012-07-03T07:16:28Z | - |
dc.date.issued | 2009-10 | - |
dc.identifier.citation | NUCLEAR MEDICINE AND BIOLOGY; Vol.36 7; 711-719 | ko_KR |
dc.identifier.issn | 0969-8051 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78283 | - |
dc.description.abstract | Objectives: We assessed the reproducibility of the kinetic analysis of 3`-deoxy-3`-[(18)F]fluorothymidine (FLT) positron emission tomography (PET) in A431 human epidermoid carcinoma and murine Lewis lung carcinoma (LLC) tumor models. Methods: We injected 7.4 MBq of FLT (n=10 for each group) and acquired 2-h dynamic PET images. A second scan was performed I day later. We calculated standardized uptake value (SUV), kinetic rate constants, volume of distribution of phosphorylated FLT (V(dm)), net influx constant (K(FUT-CA)) and influx constant by Patlak graphical analysis (K(FLT-PA)). The percent difference between measurements of a parameter was calculated to compare the reproducibilities of different parameters. Results: FLT phosphorylation was higher in mice with A431 tumors than in mice with LLC tumors (P<005). Differences in the standard deviations of the percent differences of parameters were statistically significant (P<001) in each model. In mice with A431 tumors, SUV, V(dm), K(FLT-CA) and K(FLT-PA) had standard deviations of the percent difference of <= 20%. The most reproducible parameter was K(FLT-PA), although the standard deviation (15.6%) was not statistically different from those of V(dm) (15.8%), K(FLT-CA) (17.5%) and SUV (18.9%). In mice with LLC tumors, K(1), K(1)/k(2) and k(3) had standard deviations of the percent difference of <= 20%. No macroparameters reflecting a total FLT flux had standard deviations of <= 20%. Conclusion: Our results show the reproducibility of the kinetic macroparameters of FLT PET in mouse tumors with high FLT phosphorylation. | ko_KR |
dc.description.sponsorship | This study was supported by the Real Time Molecular
Imaging Research Program of the Korean Science and Engineering Foundation, which is funded by the Ministry of Education, Science and Technology, Republic of Korea, and by the Korea Health 21 R&D Project, Ministry of Health, Welfare and Family Affairs, Republic of Korea (grant no. A062254). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER SCIENCE INC | ko_KR |
dc.subject | Reproducibility | ko_KR |
dc.subject | Kinetic analysis | ko_KR |
dc.subject | Mouse | ko_KR |
dc.subject | Positron emission tomography | ko_KR |
dc.subject | 3 `-Deoxy-3 `-[(18)F]fluorothymidine | ko_KR |
dc.title | Reproducibility of the kinetic analysis of 3 `-deoxy-3 `-[(18)F] fluorothymidine positron emission tomography in mouse tumor models | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 최승진 | - |
dc.contributor.AlternativeAuthor | 김석영 | - |
dc.contributor.AlternativeAuthor | 김수진 | - |
dc.contributor.AlternativeAuthor | 이재성 | - |
dc.contributor.AlternativeAuthor | 이상주 | - |
dc.contributor.AlternativeAuthor | 박수아 | - |
dc.contributor.AlternativeAuthor | 이승진 | - |
dc.contributor.AlternativeAuthor | 윤성철 | - |
dc.contributor.AlternativeAuthor | 임기춘 | - |
dc.contributor.AlternativeAuthor | 오승준 | - |
dc.contributor.AlternativeAuthor | 김상위 | - |
dc.contributor.AlternativeAuthor | 김재승 | - |
dc.contributor.AlternativeAuthor | 류진숙 | - |
dc.contributor.AlternativeAuthor | 문대혁 | - |
dc.identifier.doi | 10.1016/j.nucmedbio.2009.06.001 | - |
dc.citation.journaltitle | NUCLEAR MEDICINE AND BIOLOGY | - |
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dc.description.tc | 3 | - |
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