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In Vivo Imaging of Sentinel Nodes Using Fluorescent Silica Nanoparticles in Living Mice

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dc.contributor.authorJeon, Yong Hyun-
dc.contributor.authorKim, Young-Hwa-
dc.contributor.authorChoi, Kihwan-
dc.contributor.authorPiao, Jing Yu-
dc.contributor.authorLee, Yun-Sang-
dc.contributor.authorChung, June-Key-
dc.contributor.authorLee, Myung Chul-
dc.contributor.authorChung, Doo Soo-
dc.contributor.authorKang, Keon Wook-
dc.contributor.authorLee, Jaetae-
dc.contributor.authorLee, Dong Soo-
dc.contributor.authorJeong, Jae Min-
dc.contributor.authorQuan, Bo-
dc.date.accessioned2012-07-03T08:10:55Z-
dc.date.available2012-07-03T08:10:55Z-
dc.date.issued2010-04-
dc.identifier.citationMOLECULAR IMAGING AND BIOLOGY; Vol.12 2; 155-162ko_KR
dc.identifier.issn1536-1632-
dc.identifier.urihttps://hdl.handle.net/10371/78303-
dc.description.abstractWe examine the feasibility of fluorescent imaging system for sentinel lymph node detection by using functionalized silica nanoparticles. We developed a functionalized RITC-SiO(2) nanoparticles containing fluorescent dye, C(28)H(31)N(2)O(3)Cl (rhodamine B isothiocyanate) inside, and subsequently synthesized (68)Ga-NOTA-RITC-SiO(2) nanoparticles. At 5 min after RITC-doped silica nanoparticles injection, fluorescent signals were shown in both right axillary lymph node (ALN) and injection site of living mice. Fluorescent signals were also observed at these locations in a biodistribution study. In addition, fluorescence was detected in frozen ALN sections microscopically. The percentages of doses injected per gram of tissue of axillary and brachial lymph nodes near footpad treated with (68)Ga-NOTA-RITC-SiO(2) nanoparticles were 308.3 +/- 3.4 and 41.5 +/- 6.1, respectively. Little (68)Ga radioactivity was found in other organs. Our data provide strong evidence that functionalized silica nanoparticles has a promising potential as organic lymphatic tracer in biomedical imaging such as pre- and intraoperative surgical guidance.ko_KR
dc.description.sponsorshipThis work was supported by the Interdisciplinary
Research Initiatives Program of the College of Natural Sciences and the
College of Medicine, Seoul National University 2008 and by Research Division of Human Life Science of the second stage Brain Korea 21 Project
in 2009.
ko_KR
dc.language.isoenko_KR
dc.publisherSPRINGERko_KR
dc.subjectSilica nanoparticlesko_KR
dc.subjectSentinel nodeko_KR
dc.subjectOptical imagingko_KR
dc.titleIn Vivo Imaging of Sentinel Nodes Using Fluorescent Silica Nanoparticles in Living Miceko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor전용현-
dc.contributor.AlternativeAuthor김영화-
dc.contributor.AlternativeAuthor최기환-
dc.contributor.AlternativeAuthor이윤상-
dc.contributor.AlternativeAuthor정재민-
dc.contributor.AlternativeAuthor정준기-
dc.contributor.AlternativeAuthor이동수-
dc.contributor.AlternativeAuthor이명철-
dc.contributor.AlternativeAuthor이재태-
dc.contributor.AlternativeAuthor정두수-
dc.contributor.AlternativeAuthor강건욱-
dc.identifier.doi10.1007/s11307-009-0262-8-
dc.citation.journaltitleMOLECULAR IMAGING AND BIOLOGY-
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