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Regional differences in cerebral perfusion associated with the alpha-2A-adrenergic receptor genotypes in attention deficit hyperactivity disorder

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dc.contributor.authorKim, Boong-Nyun-
dc.contributor.authorKim, Jae-Won-
dc.contributor.authorKang, Hyejin-
dc.contributor.authorCho, Soo-Churl-
dc.contributor.authorYoo, Hee-Jeong-
dc.contributor.authorLee, Dong Soo-
dc.contributor.authorHong, Soon-Beom-
dc.contributor.authorShin, Min-Sup-
dc.date.accessioned2012-07-03T08:35:32Z-
dc.date.available2012-07-03T08:35:32Z-
dc.date.issued2010-09-
dc.identifier.citationJOURNAL OF PSYCHIATRY & NEUROSCIENCE; Vol.35 5; 330-336ko_KR
dc.identifier.issn1180-4882-
dc.identifier.urihttps://hdl.handle.net/10371/78316-
dc.description.abstractBackground: Neurobiologic studies have suggested that dysregulation of central noradrenergic systems may be involved in the pathophysiology of attention deficit hyperactivity disorder (ADHD), and it has been hypothesized that genetic changes in the norepinephrine pathways might contribute to dysfunction of the prefrontal cortex circuits in ADHD. We previously reported decreased cerebral blood flow in the right lateral prefrontal cortex and both orbitofrontal cortices in children with ADHD. Genetic investigations have shown that the alpha-2A-adrenergic receptor gene (ADRA2A) is associated with ADHD. Our aim was to examine whether the presence of a risk allele of the ADRA2A MspI polymorphism is associated with differences in regional cerebral blood flow in boys with ADHD. Methods: We recruited 21 Korean boys with ADHD (mean age 9.9, standard deviation [SD] 2.7 yr) and 11 age-and sex-matched controls (mean age 10.6 [SD 2.1] yr). Each participant underwent technetium-99m-hexamethylpropylene amine oxime ((99m)Tc-HMPAO) single-photon emission computed tomography. We performed image analyses with voxel-wise t statistics using SPM2. Results: We found regional hypoperfusion in the prefrontal regions, including the right orbitofrontal and right medial gyri, and the bilateral putamen and cerebellum in boys with ADHD relative to controls (p < 0.0005, uncorrected for multiple comparisons). Boys with ADHD who carried the C allele (n = 13) at the ADRA2A MspI polymorphism had reduced perfusion in the bilateral orbitofrontal regions compared with those without the C allele (n = 8) (p < 0.0005, uncorrected for multiple comparisons). Limitations: This study was limited by the small sample size, and we did not obtain genetic data from the controls. Conclusion: Our findings suggest that regional differences in cerebral perfusion in the orbitofrontal cortex represent an intermediate neuroimaging phenotype associated with the ADRA2A MspI polymorphism; these data support the validity of the noradrenergic hypothesis regarding the pathophysiology of ADHD.ko_KR
dc.description.sponsorshipThis work was supported by the Korea Research
Foundation Grant funded by the Korean Government (KRF-
2006–003-E00192).
ko_KR
dc.language.isoenko_KR
dc.publisherCMA-CANADIAN MEDICAL ASSOCko_KR
dc.titleRegional differences in cerebral perfusion associated with the alpha-2A-adrenergic receptor genotypes in attention deficit hyperactivity disorderko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김붕년-
dc.contributor.AlternativeAuthor김재원-
dc.contributor.AlternativeAuthor강혜진-
dc.contributor.AlternativeAuthor조수철-
dc.contributor.AlternativeAuthor신민섭-
dc.contributor.AlternativeAuthor유희정-
dc.contributor.AlternativeAuthor홍순범-
dc.contributor.AlternativeAuthor이동수-
dc.identifier.doi10.1503/jpn.090168-
dc.citation.journaltitleJOURNAL OF PSYCHIATRY & NEUROSCIENCE-
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College of Medicine/School of Medicine (의과대학/대학원)Nuclear Medicine (핵의학전공)Journal Papers (저널논문_핵의학전공)
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