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Differential expression of ABO antigens in normal and altered skin conditions

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Authors
Lee, D.; Oh, J.; Kwon, I.; Lee, S.; Yoon, H.; Chung, J.; Seo, E.; Kim, Y.
Issue Date
2010-04
Publisher
NATURE PUBLISHING GROUP
Citation
JOURNAL OF INVESTIGATIVE DERMATOLOGY; Vol.130 ; S72-S72
Abstract
Since its discovery by Karl Landsteiner in 1900, ABO blood group antigens have played a pivotal
role in transfusion medicine. Recently, their possible roles in inflammation and cancer have been
proposed; however, their role in skin remains elusive. To elucidate their expression and function
in skin, semiquantitative immunohistochemical analyses using monoclonal anti-A, B, or, H antibody
were performed for the specimens diagnosed as psoriasis, atopic dermatitis, ichthyosis vulgaris,
cellulitis, and cutaneous lupus erythematosus, and for 2-MED ultraviolet (UV)-irradiated
skin and normal control. In normal skin, A/B antigen was mainly expressed in stratum granulosum,
while H antigen was in stratum spinosum. In psoriasis and atopic dermatitis, A or B antigen expression
showed an appreciable decrease in stratum granulosum with a slight increase in stratum spinosum,
and H antigen was extensively stained in stratum spinosum. Although A/B antigen expression
also decreased in ichthyosis vulgaris, it was not evident as psoriasis or atopic dermatitis. A/B
antigen expression in cellulitis and cutaneous lupus erythematosus decreased in stratum granulosum,
but increased considerably in stratum corneum, stratum spinosum. In UV-irradiated skin, A/B
antigen expression in stratum granulosum were decreased, but H antigen expression showed marked
increase in stratum spinosum and stratum basale. Real-time RT-PCR revealed that transferase A
and B decreased after the UV irradiation, whereas related glycosyltransferase including FUT1,
B4GALT1,2,3,4, B3GNT5, B4GALT6 increased at 24h after the irradiation. In conclusion, the expression
of ABO blood group antigen showed a differential distribution and intensity according to skin
disorders, suggesting that ABO blood groups might be implicated in the pathogenesis of various
skin diseases in the aspect of differentiation and inflammation.
ISSN
0022-202X
Language
English
URI
https://hdl.handle.net/10371/78381
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College of Medicine/School of Medicine (의과대학/대학원)Dermatology (피부과학전공)Journal Papers (저널논문_피부과학전공)
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