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Tumor Targeting Chitosan Nanoparticles for Dual-Modality Optical/MR Cancer Imaging
DC Field | Value | Language |
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dc.contributor.author | Nam, Taehwan | - |
dc.contributor.author | Park, Sangjin | - |
dc.contributor.author | Lee, Seung-Young | - |
dc.contributor.author | Park, Kyeongsoon | - |
dc.contributor.author | Song, In Chan | - |
dc.contributor.author | Leary, James J. | - |
dc.contributor.author | Kwon, Ick Chan | - |
dc.contributor.author | Jeong, Seo Young | - |
dc.contributor.author | Kim, Kwangmeyung | - |
dc.contributor.author | Yuk, Simseok Andrew | - |
dc.contributor.author | Han, Moon Hee | - |
dc.contributor.author | Choi, Kuiwon | - |
dc.date.accessioned | 2012-07-04T05:01:40Z | - |
dc.date.available | 2012-07-04T05:01:40Z | - |
dc.date.issued | 2010-03-04 | - |
dc.identifier.citation | BIOCONJUGATE CHEMISTRY; Vol.21 4; 578-582 | ko_KR |
dc.identifier.issn | 1043-1802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78402 | - |
dc.description.abstract | We report tumor targeting nanoparticles for optical/MR dual imaging based on self-assembled glycol chitosan to be a potential multimodal imaging probe. To develop an optical/MR dual imaging probe, biocompatible and water-soluble glycol chitosan (M(w) = 50 kDa) were chemically modified with 5 beta-cholanic acid (CA), resulting in amphiphilic glycol chitosan-5 beta-cholanic acid conjugates (GC-CA). For optical imaging near-infrared fluorescence (NIRF) dye, Cy5.5, was conjugated to GC-CA resulting in Cy5-labeled GC-CA conjugates (Cy5.5-GC-CA). Moreover, in order to dictate gadolinium (Gd(III)) in the Cy5.5-GC-CA conjugates, 1,4,7,10-tetraazacyclododecane1,4,7,10-tetraacetic acid (DOTA) was directly conjugated in Cy5.5-GC-CA. Finally, the excess GdCl(3) was added to DOTA modified Cy5.5-GC-CA conjugates in distilled water (pH 5.5). The freshly prepared Gd(III) encapsulated Cy5.5-GC-CA conjugates were spontaneously self-assembled into stable Cy5.5 labeled and Gd(III) encapsulated chitosan nanoparticles (Cy5.5-CNP-Gd(III)). The Cy5.5-CNP-Gd(III) was spherical in shape and approximately 350 nm in size. From the cellular experiment, it was demonstrated that Cy5.5-CNP-Gd(III) were efficiently taken up and distributed in cytoplasm (NIRF lilter; red). When the Cy5.5-GC-Gd(III) were systemically administrated into the tail vein of tumor-bearing mice, large amounts of nanoparticles were successfully localized within the tumor, which was confirmed by noninvasive near-infrared fluorescence and MR imaging system simultaneously. These results revealed that the dual-modal imaging probe of Cy5.5-CNP-Gd(III) has the potential to be used as an optical/MR dual imaging agent for cancer treatment. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER CHEMICAL SOC | ko_KR |
dc.title | Tumor Targeting Chitosan Nanoparticles for Dual-Modality Optical/MR Cancer Imaging | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 남태환 | - |
dc.contributor.AlternativeAuthor | 박상진 | - |
dc.contributor.AlternativeAuthor | 이승영 | - |
dc.contributor.AlternativeAuthor | 박경순 | - |
dc.contributor.AlternativeAuthor | 최귀원 | - |
dc.contributor.AlternativeAuthor | 송인찬 | - |
dc.contributor.AlternativeAuthor | 한문희 | - |
dc.contributor.AlternativeAuthor | 권익찬 | - |
dc.contributor.AlternativeAuthor | 김광명 | - |
dc.contributor.AlternativeAuthor | 정서영 | - |
dc.identifier.doi | 10.1021/bc900408z | - |
dc.citation.journaltitle | BIOCONJUGATE CHEMISTRY | - |
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dc.description.tc | 19 | - |
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