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Altered resting-state connectivity in subjects at ultra-high risk for psychosis: an fMRI study

Cited 80 time in Web of Science Cited 92 time in Scopus
Authors
Shim, Geumsook; Oh, Jungsu S; Jung, Wi Hoon; Jang, Joon Hwan; Kim, Euitae; Choi, Jung-Seok; Kwon, Jun Soo; Jung, Myung Hun; Park, Hye-Yoon; Choi, Chi-Hoon
Issue Date
2010-10-11
Publisher
BIOMED CENTRAL LTD
Citation
BEHAVIORAL AND BRAIN FUNCTIONS; Vol.6 ; -
Abstract
Background: Individuals at ultra-high risk (UHR) for psychosis have self-disturbances and deficits in social cognition and functioning. Midline default network areas, including the medial prefrontal cortex and posterior cingulate cortex, are implicated in self-referential and social cognitive tasks. Thus, the neural substrates within the default mode network (DMN) have the potential to mediate self-referential and social cognitive information processing in UHR subjects. Methods: This study utilized functional magnetic resonance imaging (fMRI) to investigate resting-state DMN and task-related network (TRN) functional connectivity in 19 UHR subjects and 20 matched healthy controls. The bilateral posterior cingulate cortex was selected as a seed region, and the intrinsic organization for all subjects was reconstructed on the basis of fMRI time series correlation. Results: Default mode areas included the posterior/anterior cingulate cortices, the medial prefrontal cortex, the lateral parietal cortex, and the inferior temporal region. Task-related network areas included the dorsolateral prefrontal cortex, supplementary motor area, the inferior parietal lobule, and middle temporal cortex. Compared to healthy controls, UHR subjects exhibit hyperconnectivity within the default network regions and reduced anti-correlations (or negative correlations nearer to zero) between the posterior cingulate cortex and task-related areas. Conclusions: These findings suggest that abnormal resting-state network activity may be related with the clinical features of UHR subjects. Neurodevelopmental and anatomical alterations of cortical midline structure might underlie altered intrinsic networks in UHR subjects.
ISSN
1744-9081
Language
English
URI
http://hdl.handle.net/10371/78417
DOI
https://doi.org/10.1186/1744-9081-6-58
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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