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Altered resting-state connectivity in subjects at ultra-high risk for psychosis: an fMRI study
DC Field | Value | Language |
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dc.contributor.author | Shim, Geumsook | - |
dc.contributor.author | Oh, Jungsu S | - |
dc.contributor.author | Jung, Wi Hoon | - |
dc.contributor.author | Jang, Joon Hwan | - |
dc.contributor.author | Kim, Euitae | - |
dc.contributor.author | Choi, Jung-Seok | - |
dc.contributor.author | Kwon, Jun Soo | - |
dc.contributor.author | Jung, Myung Hun | - |
dc.contributor.author | Park, Hye-Yoon | - |
dc.contributor.author | Choi, Chi-Hoon | - |
dc.date.accessioned | 2012-07-04T05:52:04Z | - |
dc.date.available | 2012-07-04T05:52:04Z | - |
dc.date.issued | 2010-10-11 | - |
dc.identifier.citation | BEHAVIORAL AND BRAIN FUNCTIONS; Vol.6 ; - | ko_KR |
dc.identifier.issn | 1744-9081 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78417 | - |
dc.description.abstract | Background: Individuals at ultra-high risk (UHR) for psychosis have self-disturbances and deficits in social cognition and functioning. Midline default network areas, including the medial prefrontal cortex and posterior cingulate cortex, are implicated in self-referential and social cognitive tasks. Thus, the neural substrates within the default mode network (DMN) have the potential to mediate self-referential and social cognitive information processing in UHR subjects. Methods: This study utilized functional magnetic resonance imaging (fMRI) to investigate resting-state DMN and task-related network (TRN) functional connectivity in 19 UHR subjects and 20 matched healthy controls. The bilateral posterior cingulate cortex was selected as a seed region, and the intrinsic organization for all subjects was reconstructed on the basis of fMRI time series correlation. Results: Default mode areas included the posterior/anterior cingulate cortices, the medial prefrontal cortex, the lateral parietal cortex, and the inferior temporal region. Task-related network areas included the dorsolateral prefrontal cortex, supplementary motor area, the inferior parietal lobule, and middle temporal cortex. Compared to healthy controls, UHR subjects exhibit hyperconnectivity within the default network regions and reduced anti-correlations (or negative correlations nearer to zero) between the posterior cingulate cortex and task-related areas. Conclusions: These findings suggest that abnormal resting-state network activity may be related with the clinical features of UHR subjects. Neurodevelopmental and anatomical alterations of cortical midline structure might underlie altered intrinsic networks in UHR subjects. | ko_KR |
dc.description.sponsorship | This work was supported by World Class University program through the
Korea Science and Engineering Foundation funded by the Ministry of Education, Science and Technology (R32-10142) and grant from the Seoul National University Hospital Research Fund (No: 03-2009-013). | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | BIOMED CENTRAL LTD | ko_KR |
dc.title | Altered resting-state connectivity in subjects at ultra-high risk for psychosis: an fMRI study | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 심금숙 | - |
dc.contributor.AlternativeAuthor | 오정수 | - |
dc.contributor.AlternativeAuthor | 정이훈 | - |
dc.contributor.AlternativeAuthor | 장준환 | - |
dc.contributor.AlternativeAuthor | 최치훈 | - |
dc.contributor.AlternativeAuthor | 김의태 | - |
dc.contributor.AlternativeAuthor | 박혜윤 | - |
dc.contributor.AlternativeAuthor | 최정석 | - |
dc.contributor.AlternativeAuthor | 정명훈 | - |
dc.contributor.AlternativeAuthor | 권준수 | - |
dc.identifier.doi | 10.1186/1744-9081-6-58 | - |
dc.citation.journaltitle | BEHAVIORAL AND BRAIN FUNCTIONS | - |
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