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Celecoxib inhibits cell proliferation through the activation of ERK and p38 MAPK in head and neck squamous cell carcinoma cell lines
DC Field | Value | Language |
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dc.contributor.author | Park, Seok-Woo | - |
dc.contributor.author | Kim, Hyo-Sun | - |
dc.contributor.author | Hah, Jeong-Whun | - |
dc.contributor.author | Jeong, Woo-Jin | - |
dc.contributor.author | Sung, Myung-Whun | - |
dc.contributor.author | Kim, Kwang-Hyun | - |
dc.date.accessioned | 2012-07-04T07:34:01Z | - |
dc.date.available | 2012-07-04T07:34:01Z | - |
dc.date.issued | 2010-10 | - |
dc.identifier.citation | ANTI-CANCER DRUGS; Vol.21 9; 823-830 | ko_KR |
dc.identifier.issn | 0959-4973 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78464 | - |
dc.description.abstract | It has been observed that several cyclooxygenase-2 (COX-2) inhibitory chemicals might inhibit proliferation of various cancer cells through COX-2-independent action. We also identified that celecoxib more selectively kills cell lines derived from head and neck squamous cell carcinoma (HNSCC) than its non-cancerous counterparts, irrespective of COX-2 expression. Herein, we investigated whether the regulation of mitogen-activated protein kinases activity might be one of the main mechanisms related to a conspicuous COX-2-independent tumor-killing effect of celecoxib in HNSCC cell lines. We assessed the effect of celecoxib on extracellular signal-regulated kinase (ERK), p38, and c-Jun NH2-terminal kinase activity by a transcription factor activation assay then evaluated, if these factors might be involved in the COX-2-independent tumor-killing effect of celecoxib by blocking their activity. We found that the blocking activation of ERK and/or p38 could reverse the celecoxib-induced cell growth inhibition by 50-80% in HNSCC cell lines, but it was not tested in cancer cells of other types. In conclusion, our study suggests that most COX-2-independent tumor-killing action of celecoxib is mediated by the upregulation of ERK and/or p38 activity in HNSCC cells. These results encourage investigation on the underlying mechanisms and detailed outcomes of mitogen-activated protein kinases activation by celecoxib more concisely, for using its excellent tumor-killing effect more safely in the clinical field of cancer treatment. Anti-Cancer Drugs 21:823-830 (C) 2010 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | ko_KR |
dc.subject | celecoxib | ko_KR |
dc.subject | tumor killing | ko_KR |
dc.subject | head and neck cancer | ko_KR |
dc.subject | mitogen-activated protein kinase | ko_KR |
dc.title | Celecoxib inhibits cell proliferation through the activation of ERK and p38 MAPK in head and neck squamous cell carcinoma cell lines | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박석우 | - |
dc.contributor.AlternativeAuthor | 김효선 | - |
dc.contributor.AlternativeAuthor | 하정훈 | - |
dc.contributor.AlternativeAuthor | 정우진 | - |
dc.contributor.AlternativeAuthor | 김광현 | - |
dc.contributor.AlternativeAuthor | 성명훈 | - |
dc.identifier.doi | 10.1097/CAD.0b013e32833dada8 | - |
dc.citation.journaltitle | ANTI-CANCER DRUGS | - |
dc.description.citedreference | Watson JL, 2010, MOL CARCINOGEN, V49, P13, DOI 10.1002/mc.20571 | - |
dc.description.citedreference | YANG Z, 2009, ZHONGGUO ZHONG YAO Z, V34, P1553 | - |
dc.description.citedreference | Tsutsumi R, 2008, RHEUMATOL INT, V28, P727, DOI 10.1007/s00296-007-0511-6 | - |
dc.description.citedreference | Gallicchio M, 2008, BRIT J PHARMACOL, V153, P870, DOI 10.1038/sj.bjp.0707634 | - |
dc.description.citedreference | Talbert DR, 2008, BREAST CANCER RES TR, V108, P23, DOI 10.1007/s10549-007-9575-y | - |
dc.description.citedreference | Zhang S, 2007, CLIN CANCER RES, V13, P4750, DOI 10.1158/1078-0432.CCR-07-0136 | - |
dc.description.citedreference | Dvory-Sobol H, 2006, EUR J CANCER, V42, P422, DOI 10.1016/j.ejca.2005.11.009 | - |
dc.description.citedreference | Gee J, 2006, ONCOL REP, V15, P471 | - |
dc.description.citedreference | Cho SD, 2006, EUR J CANCER PREV, V15, P57 | - |
dc.description.citedreference | Cui W, 2005, CLIN CANCER RES, V11, P8213, DOI 10.1158/1078-0432 | - |
dc.description.citedreference | Backhus LM, 2005, J THORAC CARDIOV SUR, V130, P1406, DOI 10.1016/j.jtcvs.2005.07.018 | - |
dc.description.citedreference | Kang HK, 2005, MOL CANCER THER, V4, P1358, DOI 10.1158/1535-7163.MCT-05-0139 | - |
dc.description.citedreference | da Silva GMS, 2005, BIOORG MED CHEM LETT, V15, P3506, DOI 10.1016/j.bmcl.2005.05.107 | - |
dc.description.citedreference | Maier TJ, 2005, FASEB J, V19, P1353, DOI 10.1096/fj.04-3274fje | - |
dc.description.citedreference | Steffel J, 2005, CIRCULATION, V111, P1685, DOI 10.1161/01.CIR.0000160358.63804.C9 | - |
dc.description.citedreference | Patel MI, 2005, CLIN CANCER RES, V11, P1999 | - |
dc.description.citedreference | Gao J, 2005, INT J ONCOL, V26, P737 | - |
dc.description.citedreference | Honjo S, 2005, DNA CELL BIOL, V24, P141 | - |
dc.description.citedreference | Eibl G, 2005, CANCER RES, V65, P982 | - |
dc.description.citedreference | Maier TJ, 2004, BIOCHEM PHARMACOL, V67, P1469, DOI 10.1016/j.bcp.2003.12.014 | - |
dc.description.citedreference | Shao JY, 2004, J BIOL CHEM, V279, P14287, DOI 10.1074/jbc.M313276200 | - |
dc.description.citedreference | Olson JM, 2004, TRENDS MOL MED, V10, P125, DOI 10.1016/j.molmed.2004.01.007 | - |
dc.description.citedreference | Park SW, 2003, INT J CANCER, V107, P729, DOI 10.1002/ijc.11498 | - |
dc.description.citedreference | Regan JW, 2003, LIFE SCI, V74, P143, DOI 10.1016/j.lfs.2003.09.031 | - |
dc.description.citedreference | Agarwal B, 2003, APOPTOSIS, V8, P649 | - |
dc.description.citedreference | Shao JY, 2003, CANCER RES, V63, P5218 | - |
dc.description.citedreference | Hilger RA, 2002, ONKOLOGIE, V25, P511 | - |
dc.description.citedreference | Baek SJ, 2002, J PHARMACOL EXP THER, V301, P1126 | - |
dc.description.citedreference | Elder DJE, 2002, INT J CANCER, V99, P323, DOI 10.1002/ijc.10330 | - |
dc.description.citedreference | Sheng HM, 2001, J BIOL CHEM, V276, P18075 | - |
dc.description.tc | 1 | - |
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