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Clinical Manifestations of Recurrent Parotid Pleomorphic Adenoma

Cited 21 time in Web of Science Cited 23 time in Scopus
Authors
Suh, Myung-Whan; Hah, J. Hun; Kwon, Seong Keun; Jung, Young-Ho; Kim, Kwang Hyun; Sung, Myung-Whun; Kwon, Tack-Kyun
Issue Date
2009-12
Publisher
KOREAN SOC OTORHINOLARYNGOL
Citation
CLINICAL AND EXPERIMENTAL OTORHINOLARYNGOLOGY; Vol.2 4; 193-197
Keywords
Pleomorphic adenomaRecurrenceRisk factorParotid gland
Abstract
Objectives. This study was undertaken to confirm the clinical characteristics of recurrent pleomorphic adenoma (RPA), and to identify those factors that affect the development of malignant transformation (MT) from RPA. Methods. The medical records of 270 patients, who were operated upon for parotid PA, were retrospectively reviewed. The pathologic specimens of a selected series of 23 patients were reviewed for histologic subtype and microscopic multi-nodularity. Results. Mean age of initial operation in RPA without MT (RPA(-MT)) group was significantly lower than that of primary PA group. Mean age of the revision operation in RPA with MT (RPA(+MT)) group was significantly greater than that of RPA(-MT) group. Mean interval from operation to recurrence shortened after each revision operation. The risk of MT and additional recurrence increased significantly with recurrence. In RPA(-MT) group tumor recurrence occurred in 21.4% of patients despite a clear resection margin. Conclusion. The risk factors for MT may be an age of over 45 yr and multiple recurrences. However, younger patients are more at risk of recurrence. A clear resection margin cannot guarantee a cure in RPA, and it seems that parotid pleomorphic adenomas slowly gain malignant characteristics after repeated recurrences.
ISSN
1976-8710
Language
English
URI
https://hdl.handle.net/10371/78517
DOI
https://doi.org/10.3342/ceo.2009.2.4.193
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College of Medicine/School of Medicine (의과대학/대학원)Otorhinolaryngology (이비인후과학전공)Journal Papers (저널논문_이비인후과학전공)
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