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Effects of clozapine on behavioral sensitization induced by cocaine

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dc.contributor.authorPark, Hye-Jean-
dc.contributor.authorCui, Feng Ji-
dc.contributor.authorHwang, Jae Yeon-
dc.contributor.authorKang, Ung Gu-
dc.date.accessioned2012-07-05T00:40:03Z-
dc.date.available2012-07-05T00:40:03Z-
dc.date.issued2010-01-
dc.identifier.citationPSYCHIATRY RESEARCH; Vol.175 1-2; 165-170ko_KR
dc.identifier.issn0165-1781-
dc.identifier.urihttps://hdl.handle.net/10371/78522-
dc.description.abstractUsing cocaine-sensitized mice as a model for psychosis. this study investigated whether subchronic treatment with clozapine could affect the sensitized state of the animals and examined the accompanying molecular changes in the brain. To induce sensitization, ICR mice (n = 44) were treated with cocaine for 5 days. After 7 days of withdrawal, sensitization was confirmed by a cocaine challenge. Then. the sensitized animals were treated with clozapine for 5 days and rechallenged with cocaine. The frontal cortices were removed from the mice (n = 16) 24 h after the last challenge, and the phosphorylation status of some key signaling molecules was investigated. Compared with the sensitized mice receiving the vehicle treatment, the sensitized mice receiving subchronic clozapine showed less locomotor activity, with an activity level similar to that of non-sensitized mice. However, clozapine did not directly affect the stimulatory effect of cocaine. Clozapine also reversed some of the sensitization-induced biochemical changes, including increased phosphorylation of GSK-3 beta and CREB, in the frontal cortex. Subchronic treatment with clozapine apparently de-sensitized the sensitized mice. The long-term effect of clozapine on stimulant-induced sensitization may be related to the therapeutic effect of the drug as an antipsychotic agent. Crown Copyright (C) 2008 Published by Elsevier Ltd. All fights reserved.ko_KR
dc.description.sponsorshipThis study was supported by a grant (No. 04-2006-041-0) from the Seoul National
University Hospital Research Fund, Republic of Korea.
ko_KR
dc.language.isoenko_KR
dc.publisherELSEVIER IRELAND LTDko_KR
dc.subjectAKTko_KR
dc.subjectCocaineko_KR
dc.subjectCyclic AMP response element binding proteinko_KR
dc.subjectClozapineko_KR
dc.subjectBehavioral sensitizationko_KR
dc.subjectERKko_KR
dc.subjectPrefrontal cortexko_KR
dc.subjectPsychosisko_KR
dc.subjectGlycogen synthase kinase-3ko_KR
dc.titleEffects of clozapine on behavioral sensitization induced by cocaineko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor박혜진-
dc.contributor.AlternativeAuthor황재연-
dc.contributor.AlternativeAuthor강웅구-
dc.identifier.doi10.1016/j.psychres.2008.10.005-
dc.citation.journaltitlePSYCHIATRY RESEARCH-
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