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Depressive Symptoms and Brain Metabolite Alterations in Subjects at Ultra-high Risk for Psychosis: A Preliminary Study

Cited 14 time in Web of Science Cited 16 time in Scopus
Authors
Byun, Min Soo; Choi, Jung-Seok; Yoo, So Young; Kang, Do-Hyung; Jang, Dong Pyo; Jung, Myung Hun; Lee, Jong-Min; Kwon, Jun Soo; Jang, Joon Hwan; Jung, Wi Hoon; Choi, Chi-Hoon
Issue Date
2009-12
Publisher
KOREAN NEUROPSYCHIATRIC ASSOC
Citation
PSYCHIATRY INVESTIGATION; Vol.6 4; 264-271
Keywords
DepressionMagnetic resonance spectroscopyUltra-high riskSchizophrenia
Abstract
Objective Recent neuroimaging studies have suggested that brain changes occur in subjects at Ultra-high risk (UHR) for psychosis while experiencing prodromal symptoms, among which depression may increase the risk of developing a psychotic disorder. The goal of this study is to examine brain metabolite levels in the anterior cingulate cortex, the left dorsolateral prefrontal cortex and the left thalamus in Subjects at UHR for psychosis and to compare brain metabolite levels between the UHR subjects with comorbid major depressive disorder and healthy controls. Methods Proton magnetic resonance spectroscopy was used to examine brain metabolite levels. Twenty UHR subjects and 20 age- and intelligence quotient (IQ)-matched healthy controls were included in this study. Results Overall, no significant differences were observed in any metabolite between the UHR and healthy control group. However, UHR subjects with major depressive disorder showed significantly higher myo-inositol (Ins) levels in the left thalamus, compared to the healthy control. Conclusion Our results demonstrate that increased thalamic Ins level is associated with prodromal depressive symptoms. Further longitudinal follow-up Studies with larger UHR sample sizes are required to investigate the function of Ins concentrations as a biomarker Of Vulnerability to psychosis. Psychiatry Invest 2009;6:264-271
ISSN
1738-3684
Language
English
URI
https://hdl.handle.net/10371/78526
DOI
https://doi.org/10.4306/pi.2009.6.4.264
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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