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Up-regulation of cocaine- and amphetamine-regulated transcript (CART) in the rat nucleus accumbens after repeated electroconvulsive shock

Cited 14 time in Web of Science Cited 15 time in Scopus
Authors
Roh, Myoung-Sun; Cui, Feng Ji; Ahn, Yong Min; Kang, Ung Gu
Issue Date
2009-10
Publisher
ELSEVIER IRELAND LTD
Citation
NEUROSCIENCE RESEARCH; Vol.65 2; 210-213
Keywords
CARTElectroconvulsive shockNucleus accumbensDepressionCREB
Abstract
Cocaine- and amphetamine-regulated transcript (CART) peptide regulates appetite, reward, and mood. CART expression is regulated via the protein kinase A (PKA) pathway, and electroconvulsive shock (ECS), an efficient antipsychotic and antidepressant measure, activates PKA-related signaling. Thus, we hypothesized that ECS may regulate the expression of CART. ECS given daily for five consecutive days increased CART mRNA and protein in the rat nucleus accumbens (NAc), accompanied by an increase in CREB phosphorylation. Our results suggest that ECS-induced CART up-regulation might be associated with PKA-CREB signaling, but the causal direction remains to be elucidated in future studies. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
ISSN
0168-0102
Language
English
URI
http://hdl.handle.net/10371/78551
DOI
https://doi.org/10.1016/j.neures.2009.06.013
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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