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Up-regulation of cocaine- and amphetamine-regulated transcript (CART) in the rat nucleus accumbens after repeated electroconvulsive shock
DC Field | Value | Language |
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dc.contributor.author | Roh, Myoung-Sun | - |
dc.contributor.author | Cui, Feng Ji | - |
dc.contributor.author | Ahn, Yong Min | - |
dc.contributor.author | Kang, Ung Gu | - |
dc.date.accessioned | 2012-07-05T01:51:26Z | - |
dc.date.available | 2012-07-05T01:51:26Z | - |
dc.date.issued | 2009-10 | - |
dc.identifier.citation | NEUROSCIENCE RESEARCH; Vol.65 2; 210-213 | ko_KR |
dc.identifier.issn | 0168-0102 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78551 | - |
dc.description.abstract | Cocaine- and amphetamine-regulated transcript (CART) peptide regulates appetite, reward, and mood. CART expression is regulated via the protein kinase A (PKA) pathway, and electroconvulsive shock (ECS), an efficient antipsychotic and antidepressant measure, activates PKA-related signaling. Thus, we hypothesized that ECS may regulate the expression of CART. ECS given daily for five consecutive days increased CART mRNA and protein in the rat nucleus accumbens (NAc), accompanied by an increase in CREB phosphorylation. Our results suggest that ECS-induced CART up-regulation might be associated with PKA-CREB signaling, but the causal direction remains to be elucidated in future studies. (C) 2009 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved. | ko_KR |
dc.description.sponsorship | This study was supported by a grant (KRF-2005-04-E00233)
from the Korean Research Foundation and a research fund by Shin Hae Choi (2002) from the Korean Neuropsychiatric Association. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | ELSEVIER IRELAND LTD | ko_KR |
dc.subject | CART | ko_KR |
dc.subject | Electroconvulsive shock | ko_KR |
dc.subject | Nucleus accumbens | ko_KR |
dc.subject | Depression | ko_KR |
dc.subject | CREB | ko_KR |
dc.title | Up-regulation of cocaine- and amphetamine-regulated transcript (CART) in the rat nucleus accumbens after repeated electroconvulsive shock | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 노명선 | - |
dc.contributor.AlternativeAuthor | 안용민 | - |
dc.contributor.AlternativeAuthor | 강웅구 | - |
dc.identifier.doi | 10.1016/j.neures.2009.06.013 | - |
dc.citation.journaltitle | NEUROSCIENCE RESEARCH | - |
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dc.description.tc | 3 | - |
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