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AKT1 Gene Polymorphisms and Obstetric Complications in the Patients with Schizophrenia

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dc.contributor.authorJoo, Eun-Jeong-
dc.contributor.authorLee, Kyu-Young-
dc.contributor.authorJeong, Seong-Hoon-
dc.contributor.authorRoh, Myoung-Sun-
dc.contributor.authorAhn, Yong-Min-
dc.contributor.authorKim, Yong Sik-
dc.contributor.authorKim, Se Hyun-
dc.date.accessioned2012-07-05T02:32:58Z-
dc.date.available2012-07-05T02:32:58Z-
dc.date.issued2009-06-
dc.identifier.citationPSYCHIATRY INVESTIGATION; Vol.6(2); 102-107ko_KR
dc.identifier.issn1738-3684-
dc.identifier.urihttps://hdl.handle.net/10371/78568-
dc.description.abstractObjective We performed a genetic association study with schizophrenic patients to investigate whether the V-akt murine thymoma viral oncogene homolog 1 (AKT1) gene plays a role in obstetric complications. Methods One-hundred-eighty patients with schizophrenia (male, 113; female, 67) were included. All patients fulfilled DSM-IV criteria for schizophrenia. Obstetric complications were measured by the Lewis scale. Prenatal and perinatal information was retrospectively collected from the patients` mothers. We selected six single nucleotide polymorphisms (SNPs) for the AKT1 gene: SNP1 (rs3803300), SNP2 (rs1130214), SNP3 (rs3730358), SNP4 (rs1130233), SNP5 (rs2494732), and SNPA (rs2498804). The genotype data were analyzed for an association with the Lewis total score in terms of allele, genotype, and haplotype distribution. Results The mean total Lewis scores were 1.30 +/- 1.61 for males and 1.54 +/- 1.87 for females. Higher total score tended to be correlated with an earlier age of onset of schizophrenia in females. In the total sample, no SNP was associated with obstetric complications. However, the additional analyses for male and female Subgroups found a significant association between SNPA and SNP4 and Lewis score in females (p=0.02 for SNPA, p=0.04 for SNP4). The SNP5-SNPA haplotype showed a positive association with obstetric complications (p=0.03) in the female patient group. Conclusion We found an association between SNPs in the AKT1 gene and total Lewis score measuring obstetric complications in female patients with schizophrenia. Because these findings did not Survive a correction for multiple testing, the significance should be interpreted carefully and replication studies are required.ko_KR
dc.language.isoenko_KR
dc.publisherKOREAN NEUROPSYCHIATRIC ASSOCko_KR
dc.subjectAKT1 geneko_KR
dc.subjectSchizophreniako_KR
dc.subjectAssociationko_KR
dc.subjectLewis scaleko_KR
dc.subjectObstetric complicationko_KR
dc.titleAKT1 Gene Polymorphisms and Obstetric Complications in the Patients with Schizophreniako_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor주은정-
dc.contributor.AlternativeAuthor이규영-
dc.contributor.AlternativeAuthor정성훈-
dc.contributor.AlternativeAuthor노명선-
dc.contributor.AlternativeAuthor김세현-
dc.contributor.AlternativeAuthor안용민-
dc.contributor.AlternativeAuthor김용식-
dc.identifier.doi10.4306/pi.2009.6.2.102-
dc.citation.journaltitlePSYCHIATRY INVESTIGATION-
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College of Medicine/School of Medicine (의과대학/대학원)Psychiatry (정신과학전공)Journal Papers (저널논문_정신과학전공)
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