Publications
Detailed Information
p34(SEI-1) Inhibits Doxorubicin-Induced Senescence through a Pathway Mediated by Protein Kinase C-δ and c-Jun-NH(2)-Kinase 1 Activation in Human Breast Cancer MCF7 Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sae Lo Oom | - |
dc.contributor.author | Hong, Seung-Woo | - |
dc.contributor.author | Shin, Jae-Sik | - |
dc.contributor.author | Kim, Jin Sun | - |
dc.contributor.author | Hong, Nam-Joo | - |
dc.contributor.author | Lee, Wang-Jae | - |
dc.contributor.author | Lee, Myeong-Sok | - |
dc.contributor.author | Jin, Dong-Hoon | - |
dc.contributor.author | Kim, Dae Jin | - |
dc.contributor.author | Ko, Seong-Gyu | - |
dc.date.accessioned | 2012-07-10T01:09:59Z | - |
dc.date.available | 2012-07-10T01:09:59Z | - |
dc.date.issued | 2009-11 | - |
dc.identifier.citation | MOLECULAR CANCER RESEARCH; Vol.7(11); 1845-1853 | ko_KR |
dc.identifier.issn | 1541-7786 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78678 | - |
dc.description.abstract | In this study, we describe a novel function of the p34(SEI-1) protein, which is both an oncogenic protein and a positive regulator of the cell cycle. The p34(SEI-1) protein was found to inhibit doxorubicin-induced senescence. We investigated the molecular mechanisms of the inhibitory effect of p34(SEI-1) on senescence. First, we found that the activation of protein kinase C-delta (PKC-delta), which is cleaved into a 38 kDa active form from a 78 kDa pro-form, induced after doxorubicin treatment, was inhibited by p34(SEI-1). Furthermore, p34(SEI-1) induced the ubiquitination of PKC-delta. Yet, there is no interaction between p34(SEI-1) and PKC-delta. We also found that the phosphorylation of c-Jun-NH(2)-kinase 1 (JNK1) induced after doxorubicin treatment was suppressed by p34(SEI-1), but not in JNK2. Consistently, pharmacologic or genetic inactivation of either PKC-delta or JNK1 was found to inhibit doxorubicin-induced senescence. In addition, the genetic inactivation of PKC-delta by PKC-delta small interfering RNA resulted in an inhibition of JNK1 activation, but PKC-delta expression was not inactivated by JNK1 small interfering RNA, implying that the activation of JNK1 could be dependently induced by PKC-delta. Therefore, p34(SEI-1) inhibits senescence by inducing PKC-delta ubiquitination and preventing PKC-delta-dependent phosphorylation of JNK1. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | AMER ASSOC CANCER RESEARCH | ko_KR |
dc.title | p34(SEI-1) Inhibits Doxorubicin-Induced Senescence through a Pathway Mediated by Protein Kinase C-δ and c-Jun-NH(2)-Kinase 1 Activation in Human Breast Cancer MCF7 Cells | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 이새로움 | - |
dc.contributor.AlternativeAuthor | 홍승우 | - |
dc.contributor.AlternativeAuthor | 신재식 | - |
dc.contributor.AlternativeAuthor | 김진선 | - |
dc.contributor.AlternativeAuthor | 고성규 | - |
dc.contributor.AlternativeAuthor | 홍남주 | - |
dc.contributor.AlternativeAuthor | 김대진 | - |
dc.contributor.AlternativeAuthor | 이왕재 | - |
dc.contributor.AlternativeAuthor | 진동훈 | - |
dc.contributor.AlternativeAuthor | 이명석 | - |
dc.identifier.doi | 10.1158/1541-7786.MCR-09-0086 | - |
dc.citation.journaltitle | MOLECULAR CANCER RESEARCH | - |
dc.description.citedreference | Kim NY, 2009, ARCH PHARM RES, V32, P737, DOI 10.1007/s12272-009-1513-6 | - |
dc.description.citedreference | Chen D, 2007, J BIOL CHEM, V282, P33776, DOI 10.1074/jbc.M703320200 | - |
dc.description.citedreference | Oleinik NV, 2007, ONCOGENE, V26, P7222, DOI 10.1038/sj.onc.1210526 | - |
dc.description.citedreference | Deng R, 2006, ONCOGENE, V25, P7070, DOI 10.1038/sj.onc.1209686 | - |
dc.description.citedreference | Hong IK, 2006, J BIOL CHEM, V281, P24279, DOI 10.1074/jbc.M601209200 | - |
dc.description.citedreference | Cerda SR, 2006, ONCOGENE, V25, P3123, DOI 10.1038/sj.onc.1209360 | - |
dc.description.citedreference | Jackson JG, 2006, MOL CELL BIOL, V26, P2501, DOI 10.1128/MCB.26.7.2501-2510.2006 | - |
dc.description.citedreference | Tang DJ, 2005, CANCER RES, V65, P6504 | - |
dc.description.citedreference | Wheaton K, 2004, MOL CELL BIOL, V24, P7298 | - |
dc.description.citedreference | Jung MS, 2004, J BIOL CHEM, V279, P17765, DOI 10.1074/jbc.M305015200 | - |
dc.description.citedreference | Li J, 2004, BIOCHEMISTRY-US, V43, P4394, DOI 10.1021/bi035601s | - |
dc.description.citedreference | Tang TCM, 2002, CANCER RES, V62, P7157 | - |
dc.description.citedreference | Hutter E, 2002, EXP GERONTOL, V37, P1165 | - |
dc.description.citedreference | Elmore LW, 2002, J BIOL CHEM, V277, P35509, DOI 10.1074/jbc.M205477200 | - |
dc.description.citedreference | Haq R, 2002, CANCER RES, V62, P5076 | - |
dc.description.citedreference | Han ZY, 2002, J BIOL CHEM, V277, P17154, DOI 10.1074/jbc.M112401200 | - |
dc.description.citedreference | Macip S, 2002, EMBO J, V21, P2180 | - |
dc.description.citedreference | Hsu SIH, 2001, EMBO J, V20, P2273 | - |
dc.description.citedreference | Ferbeyre G, 2000, GENE DEV, V14, P2015 | - |
dc.description.citedreference | Pearson M, 2000, NATURE, V406, P207 | - |
dc.description.citedreference | Dumont P, 2000, FREE RADICAL BIO MED, V28, P361 | - |
dc.description.citedreference | Sugimoto M, 1999, GENE DEV, V13, P3027 | - |
dc.description.citedreference | Reed JC, 1999, J CLIN ONCOL, V17, P2941 | - |
dc.description.citedreference | Chang BD, 1999, ONCOGENE, V18, P4808 | - |
dc.description.citedreference | Chang BD, 1999, CANCER RES, V59, P3761 | - |
dc.description.citedreference | Fang L, 1999, ONCOGENE, V18, P2789 | - |
dc.description.citedreference | Wang YC, 1999, ONCOGENE, V18, P2643 | - |
dc.description.citedreference | Gschwendt M, 1999, EUR J BIOCHEM, V259, P555 | - |
dc.description.citedreference | Hoglund M, 1998, GENE CHROMOSOME CANC, V21, P8 | - |
dc.description.citedreference | Xu HJ, 1997, ONCOGENE, V15, P2589 | - |
dc.description.citedreference | Uhrbom L, 1997, ONCOGENE, V15, P505 | - |
dc.description.citedreference | Hortobagyi GN, 1997, DRUGS, V54, P1 | - |
dc.description.citedreference | DIAZ L, 1997, J BIOL CHEM, V25, P11350 | - |
dc.description.citedreference | Thompson FH, 1996, CANCER GENET CYTOGEN, V87, P55 | - |
dc.description.citedreference | DIMRI GP, 1995, P NATL ACAD SCI USA, V92, P9363 | - |
dc.description.citedreference | YIN XM, 1994, NATURE, V369, P321 | - |
dc.description.citedreference | KANE DJ, 1993, SCIENCE, V262, P1274 | - |
dc.description.citedreference | JASNY BR, 1984, J EXP MED, V159, P1741 | - |
dc.description.citedreference | PACKER L, 1977, NATURE, V267, P423 | - |
dc.description.tc | 2 | - |
- Appears in Collections:
- Files in This Item:
- There are no files associated with this item.
Item View & Download Count
Items in S-Space are protected by copyright, with all rights reserved, unless otherwise indicated.