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p34(SEI-1) Inhibits Doxorubicin-Induced Senescence through a Pathway Mediated by Protein Kinase C-δ and c-Jun-NH(2)-Kinase 1 Activation in Human Breast Cancer MCF7 Cells

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dc.contributor.authorLee, Sae Lo Oom-
dc.contributor.authorHong, Seung-Woo-
dc.contributor.authorShin, Jae-Sik-
dc.contributor.authorKim, Jin Sun-
dc.contributor.authorHong, Nam-Joo-
dc.contributor.authorLee, Wang-Jae-
dc.contributor.authorLee, Myeong-Sok-
dc.contributor.authorJin, Dong-Hoon-
dc.contributor.authorKim, Dae Jin-
dc.contributor.authorKo, Seong-Gyu-
dc.date.accessioned2012-07-10T01:09:59Z-
dc.date.available2012-07-10T01:09:59Z-
dc.date.issued2009-11-
dc.identifier.citationMOLECULAR CANCER RESEARCH; Vol.7(11); 1845-1853ko_KR
dc.identifier.issn1541-7786-
dc.identifier.urihttps://hdl.handle.net/10371/78678-
dc.description.abstractIn this study, we describe a novel function of the p34(SEI-1) protein, which is both an oncogenic protein and a positive regulator of the cell cycle. The p34(SEI-1) protein was found to inhibit doxorubicin-induced senescence. We investigated the molecular mechanisms of the inhibitory effect of p34(SEI-1) on senescence. First, we found that the activation of protein kinase C-delta (PKC-delta), which is cleaved into a 38 kDa active form from a 78 kDa pro-form, induced after doxorubicin treatment, was inhibited by p34(SEI-1). Furthermore, p34(SEI-1) induced the ubiquitination of PKC-delta. Yet, there is no interaction between p34(SEI-1) and PKC-delta. We also found that the phosphorylation of c-Jun-NH(2)-kinase 1 (JNK1) induced after doxorubicin treatment was suppressed by p34(SEI-1), but not in JNK2. Consistently, pharmacologic or genetic inactivation of either PKC-delta or JNK1 was found to inhibit doxorubicin-induced senescence. In addition, the genetic inactivation of PKC-delta by PKC-delta small interfering RNA resulted in an inhibition of JNK1 activation, but PKC-delta expression was not inactivated by JNK1 small interfering RNA, implying that the activation of JNK1 could be dependently induced by PKC-delta. Therefore, p34(SEI-1) inhibits senescence by inducing PKC-delta ubiquitination and preventing PKC-delta-dependent phosphorylation of JNK1.ko_KR
dc.language.isoenko_KR
dc.publisherAMER ASSOC CANCER RESEARCHko_KR
dc.titlep34(SEI-1) Inhibits Doxorubicin-Induced Senescence through a Pathway Mediated by Protein Kinase C-δ and c-Jun-NH(2)-Kinase 1 Activation in Human Breast Cancer MCF7 Cellsko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor이새로움-
dc.contributor.AlternativeAuthor홍승우-
dc.contributor.AlternativeAuthor신재식-
dc.contributor.AlternativeAuthor김진선-
dc.contributor.AlternativeAuthor고성규-
dc.contributor.AlternativeAuthor홍남주-
dc.contributor.AlternativeAuthor김대진-
dc.contributor.AlternativeAuthor이왕재-
dc.contributor.AlternativeAuthor진동훈-
dc.contributor.AlternativeAuthor이명석-
dc.identifier.doi10.1158/1541-7786.MCR-09-0086-
dc.citation.journaltitleMOLECULAR CANCER RESEARCH-
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College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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