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Cell cycle regulators, APC/β-catenin, NF-κB and Epstein-Barr virus in gastric carcinomas

Cited 28 time in Web of Science Cited 29 time in Scopus
Authors
Kim, Bomi; Byun, Sun-Ju; Kim, Young A.; Kim, Ji Eun; Kim, Woo Ho; Chang, Mee Soo; Lee, Byung Lan
Issue Date
2010-01
Publisher
TAYLOR & FRANCIS LTD
Citation
PATHOLOGY; Vol.42(1); 58-65
Keywords
p53Epstein-Barr virusstomach neoplasmprognosisNF-κBp21APCβ-catenin
Abstract
Aims: To evaluate the clinicopathological value of cell cycle regulators, the Writ pathway, the NF-beta B pathway and Epstein-Barr virus (EBV) and to assess their relationships in gastric carcinoma. Methods: We investigated cell cycle regulators (p53, p21, Rb), APC, beta-catenin and NF-kappa B using immunohistochemistry and EBV using in situ hybridisation for EBV encoded small RNAs in 117 cases of gastric carcinoma. Results: p53 overexpression was more frequently observed in advanced gastric carcinoma and lymph node metastasis than in early carcinoma or in the absence of metastasis (p < 0.05). p21 loss was positively correlated with APC loss, but inversely correlated with beta-catenin nuclear accumulation and NF-kappa B positivity (p < 0.05). EBV positive gastric carcinomas were located in the upper third of the stomach, and more were of the diffuse or mixed types than the EBV negative group (p < 0.05). EBV infection was positively correlated with p21 loss and APC loss and inversely correlated with beta-catenin alteration (p < 0.05). In multivariate analysis, patient age, TNM stage and p53 were independent prognostic factors for gastric carcinoma. Conclusions: p53 status is a prognostic marker for gastric carcinoma. p21, APC, beta-catenin and NF-kappa B may be functionally interrelated in gastric carcinogenesis. Loss of p21 and APC may be involved in the carcinogenesis of EBV positive gastric carcinomas.
ISSN
0031-3025
Language
English
URI
https://hdl.handle.net/10371/78682
DOI
https://doi.org/10.3109/00313020903356392
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College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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