Nuclear Factor-Kappa B Inhibition Reduces Markedly Cell Proliferation in Epstein-Barr Virus-Infected Stomach Cancer, But Affects Variably in Epstein-Barr Virus-Negative Stomach Cancer

Abstract

Nuclear factor-kappa B (NF-kappa B) inhibition by NF-kappa B p65-specific siRNA induced a near-cessation of cell proliferation in EBV-positive stomach cancer cell, and notably diminished cell proliferation in EBV- positive Raji lymphoma cell. In EBV-negative stomach cancer cells, NF-kappa B inhibition affected variably cell proliferation. Regardless of cell type, NF-kappa B inhibition suppressed antiapoptotic function of NF-kappa B, and tended to promote the nuclear accumulation of beta-catenin. This inverse relationship between NF-kappa B and beta-catenin was evident in 120 resected gastric carcinomas. Conclusively, NF-kappa B inhibition may be beneficial in the therapy of EBV-positive stomach cancer, but influence variously EBV-negative stomach cancer.