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Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens
DC Field | Value | Language |
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dc.contributor.author | Kang, Hee Gyung | - |
dc.contributor.author | Lee, Jung Eun | - |
dc.contributor.author | Yang, Seung Hee | - |
dc.contributor.author | Lee, Se Han | - |
dc.contributor.author | Strom, Terry B. | - |
dc.contributor.author | Lee, Dong-Sup | - |
dc.contributor.author | Kim, Yon Su | - |
dc.contributor.author | Oh, Keunhee | - |
dc.contributor.author | Gao, Wenda | - |
dc.date.accessioned | 2012-07-10T01:51:19Z | - |
dc.date.available | 2012-07-10T01:51:19Z | - |
dc.date.issued | 2010-04 | - |
dc.identifier.citation | IMMUNOLOGY; Vol.129(4); 567-577 | ko_KR |
dc.identifier.issn | 0019-2805 | - |
dc.identifier.uri | https://hdl.handle.net/10371/78685 | - |
dc.description.abstract | The maturation of antigen-presenting dendritic cells (DCs) serves as an important determinant for the regulation of immunity, and overall immune response. We hypothesized that a reduced immune response to donor alloantigens and improved allograft survival could be induced by pre-treating recipients with bone-marrow-derived donor-strain fixed immature DCs (FIDCs). Donor-strain-derived mature and immature DCs were fixed before grafting to ensure that they possessed a stable immunogenic phenotype. The fixed mature DCs effectively induced allogeneic T-cell proliferation in recipients, whereas FIDCs were unable to elicit an allogeneic T-cell response. T cells that had previously been exposed to FIDCs maintained naive phenotypes and were unable to extensively divide after injection into lethally irradiated donor-strain mice. The pre-treatment of recipients with donor-strain FIDCs markedly prolonged the survival of islet as well as skin allografts. However, T-cell hyporesponsiveness induced by FIDC injection was abrogated by the depletion of CD4+ CD25+ T cells. Consequently, FIDC-induced T-cell hyporesponsiveness could reflect anergy rather than specific deletion. Our findings suggest that FIDCs of donor strain could be used to induce long-term graft survival. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY-BLACKWELL PUBLISHING, INC | ko_KR |
dc.subject | clonal hyporeactivity | ko_KR |
dc.subject | dendritic cells | ko_KR |
dc.subject | tolerance | ko_KR |
dc.subject | maturation | ko_KR |
dc.subject | long-term graft survival | ko_KR |
dc.title | Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 강희경 | - |
dc.contributor.AlternativeAuthor | 이정은 | - |
dc.contributor.AlternativeAuthor | 양승희 | - |
dc.contributor.AlternativeAuthor | 이세한 | - |
dc.contributor.AlternativeAuthor | 오근희 | - |
dc.contributor.AlternativeAuthor | 김연수 | - |
dc.contributor.AlternativeAuthor | 이동섭 | - |
dc.identifier.doi | 10.1111/j.1365-2567.2009.03158.x | - |
dc.citation.journaltitle | IMMUNOLOGY | - |
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dc.description.tc | 0 | - |
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