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Donor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigens

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dc.contributor.authorKang, Hee Gyung-
dc.contributor.authorLee, Jung Eun-
dc.contributor.authorYang, Seung Hee-
dc.contributor.authorLee, Se Han-
dc.contributor.authorStrom, Terry B.-
dc.contributor.authorLee, Dong-Sup-
dc.contributor.authorKim, Yon Su-
dc.contributor.authorOh, Keunhee-
dc.contributor.authorGao, Wenda-
dc.date.accessioned2012-07-10T01:51:19Z-
dc.date.available2012-07-10T01:51:19Z-
dc.date.issued2010-04-
dc.identifier.citationIMMUNOLOGY; Vol.129(4); 567-577ko_KR
dc.identifier.issn0019-2805-
dc.identifier.urihttps://hdl.handle.net/10371/78685-
dc.description.abstractThe maturation of antigen-presenting dendritic cells (DCs) serves as an important determinant for the regulation of immunity, and overall immune response. We hypothesized that a reduced immune response to donor alloantigens and improved allograft survival could be induced by pre-treating recipients with bone-marrow-derived donor-strain fixed immature DCs (FIDCs). Donor-strain-derived mature and immature DCs were fixed before grafting to ensure that they possessed a stable immunogenic phenotype. The fixed mature DCs effectively induced allogeneic T-cell proliferation in recipients, whereas FIDCs were unable to elicit an allogeneic T-cell response. T cells that had previously been exposed to FIDCs maintained naive phenotypes and were unable to extensively divide after injection into lethally irradiated donor-strain mice. The pre-treatment of recipients with donor-strain FIDCs markedly prolonged the survival of islet as well as skin allografts. However, T-cell hyporesponsiveness induced by FIDC injection was abrogated by the depletion of CD4+ CD25+ T cells. Consequently, FIDC-induced T-cell hyporesponsiveness could reflect anergy rather than specific deletion. Our findings suggest that FIDCs of donor strain could be used to induce long-term graft survival.ko_KR
dc.language.isoenko_KR
dc.publisherWILEY-BLACKWELL PUBLISHING, INCko_KR
dc.subjectclonal hyporeactivityko_KR
dc.subjectdendritic cellsko_KR
dc.subjecttoleranceko_KR
dc.subjectmaturationko_KR
dc.subjectlong-term graft survivalko_KR
dc.titleDonor-strain-derived immature dendritic cell pre-treatment induced hyporesponsiveness against allogeneic antigensko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor강희경-
dc.contributor.AlternativeAuthor이정은-
dc.contributor.AlternativeAuthor양승희-
dc.contributor.AlternativeAuthor이세한-
dc.contributor.AlternativeAuthor오근희-
dc.contributor.AlternativeAuthor김연수-
dc.contributor.AlternativeAuthor이동섭-
dc.identifier.doi10.1111/j.1365-2567.2009.03158.x-
dc.citation.journaltitleIMMUNOLOGY-
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College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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