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Focal adhesion kinase (FAK) gene amplification and its clinical implications in gastric cancer

Cited 44 time in Web of Science Cited 43 time in Scopus
Authors
Park, Joo Hyun; Lee, Byung-Lan; Yoon, Jiyeon; Kim, Jin; Yang, Han-Kwang; Kim, Woo Ho; Kim, Min A.
Issue Date
2010-12
Publisher
W B SAUNDERS CO-ELSEVIER INC
Citation
HUMAN PATHOLOGY; Vol.41(12); 1664-1673
Keywords
Stomach neoplasmIn situ hybridizationPTK2 proteinGene expressionPrognosis
Abstract
Focal adhesion kinase, a nonreceptor tyrosine kinase, is known to be associated with tumor progression in various tumors Because the clinical implications of focal adhesion kinase overexpression in gastric cancer have been inconsistent, we extended previous studies and evaluated focal adhesion kinase gene amplification as well as its protein expression Immunohistochemical tissue array analysis showed that focal adhesion kinase immunoreactivity was present in both the cytoplasm and membrane of gastric cancer cells Diffuse immunoreactivity of focal adhesion kinase protein in cytoplasm or membrane was found in 240 (54%) or 263 (59%) of 444 surgical samples, respectively, and positively correlated with tumor size, depth of tumor infiltration, nodal metastasis, distant metastasis, lymphatic invasion, and venous invasion (P < 001) Regarding focal adhesion kinase gene amplification, fluorescence in situ hybridization analysis showed focal adhesion kinase gene amplification in 34 (8 9%) of 384 gastric cancer specimens, whereas there was no amplification in any case of atrophy, intestinal metaplasia, or adenoma/dysplasia Focal adhesion kinase gene amplification was positively associated with age (P = 012), tumor size (P = 007), nodal metastasis (P = 021), distant metastasis (P = 029), lymphatic invasion (P = 006), venous invasion (P = 032), and perineural invasion (P = 023) Focal adhesion kinase protein expression and gene amplification were positively correlated with each other, and each of them was found to be an Independent poor prognostic factor (P < 01) In conclusion, our results showed that either focal adhesion kinase protein expression or focal adhesion kinase gene amplification was significantly correlated with cancer progression and poor prognosis in gastric cancer Thus, focal adhesion kinase gene amplification could supplement its protein expression for the diagnosis and treatment of gastric cancer.
ISSN
0046-8177
Language
English
URI
http://hdl.handle.net/10371/78696
DOI
https://doi.org/10.1016/j.humpath.2010.06.004
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College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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