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Focal adhesion kinase (FAK) gene amplification and its clinical implications in gastric cancer

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dc.contributor.authorPark, Joo Hyun-
dc.contributor.authorLee, Byung-Lan-
dc.contributor.authorYoon, Jiyeon-
dc.contributor.authorKim, Jin-
dc.contributor.authorYang, Han-Kwang-
dc.contributor.authorKim, Woo Ho-
dc.contributor.authorKim, Min A.-
dc.date.accessioned2012-07-10T04:33:35Z-
dc.date.available2012-07-10T04:33:35Z-
dc.date.issued2010-12-
dc.identifier.citationHUMAN PATHOLOGY; Vol.41(12); 1664-1673ko_KR
dc.identifier.issn0046-8177-
dc.identifier.urihttp://hdl.handle.net/10371/78696-
dc.description.abstractFocal adhesion kinase, a nonreceptor tyrosine kinase, is known to be associated with tumor progression in various tumors Because the clinical implications of focal adhesion kinase overexpression in gastric cancer have been inconsistent, we extended previous studies and evaluated focal adhesion kinase gene amplification as well as its protein expression Immunohistochemical tissue array analysis showed that focal adhesion kinase immunoreactivity was present in both the cytoplasm and membrane of gastric cancer cells Diffuse immunoreactivity of focal adhesion kinase protein in cytoplasm or membrane was found in 240 (54%) or 263 (59%) of 444 surgical samples, respectively, and positively correlated with tumor size, depth of tumor infiltration, nodal metastasis, distant metastasis, lymphatic invasion, and venous invasion (P < 001) Regarding focal adhesion kinase gene amplification, fluorescence in situ hybridization analysis showed focal adhesion kinase gene amplification in 34 (8 9%) of 384 gastric cancer specimens, whereas there was no amplification in any case of atrophy, intestinal metaplasia, or adenoma/dysplasia Focal adhesion kinase gene amplification was positively associated with age (P = 012), tumor size (P = 007), nodal metastasis (P = 021), distant metastasis (P = 029), lymphatic invasion (P = 006), venous invasion (P = 032), and perineural invasion (P = 023) Focal adhesion kinase protein expression and gene amplification were positively correlated with each other, and each of them was found to be an Independent poor prognostic factor (P < 01) In conclusion, our results showed that either focal adhesion kinase protein expression or focal adhesion kinase gene amplification was significantly correlated with cancer progression and poor prognosis in gastric cancer Thus, focal adhesion kinase gene amplification could supplement its protein expression for the diagnosis and treatment of gastric cancer.ko_KR
dc.description.sponsorshipSupported by grant 03-2010-0030 from the SNUH Research Fund.ko_KR
dc.language.isoenko_KR
dc.publisherW B SAUNDERS CO-ELSEVIER INCko_KR
dc.subjectStomach neoplasmko_KR
dc.subjectIn situ hybridizationko_KR
dc.subjectPTK2 proteinko_KR
dc.subjectGene expressionko_KR
dc.subjectPrognosisko_KR
dc.titleFocal adhesion kinase (FAK) gene amplification and its clinical implications in gastric cancerko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor박주현-
dc.contributor.AlternativeAuthor이병란-
dc.contributor.AlternativeAuthor윤지연-
dc.contributor.AlternativeAuthor김진-
dc.contributor.AlternativeAuthor김민아-
dc.contributor.AlternativeAuthor양한광-
dc.contributor.AlternativeAuthor김우호-
dc.identifier.doi10.1016/j.humpath.2010.06.004-
dc.citation.journaltitleHUMAN PATHOLOGY-
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College of Medicine/School of Medicine (의과대학/대학원)Anatomy (해부학전공)Journal Papers (저널논문_해부학전공)
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