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Urocanic acid-modified chitosan-mediated PTEN delivery via aerosol suppressed lung tumorigenesis in K-ras(LA1) mice

Cited 46 time in Web of Science Cited 56 time in Scopus
Authors

Jin, H.; Xu, C-X; Kim, H-W; Chung, Y-S; Shin, J-Y; Chang, S-H; Park, S-J; Lee, E-S; Hwang, S-K; Kwon, J-T; Minai-Tehrani, A.; Woo, M.; Noh, M-S; Youn, H-J; Kim, D-Y; Yoon, B-I; Lee, K-H; Kim, T-H; Cho, S.; Cho, M-H

Issue Date
2008-05
Publisher
Nature Publishing Group
Citation
Cancer Gene Therapy, Vol.15 No.5, pp.275-283
Abstract
The low efficiency of conventional therapies in achieving long-term survival of lung cancer patients calls for development of novel options. Revisiting of aerosol gene delivery may provide an alternative for safe and effective treatment for lung cancer. In this study, imidazole ring-containing urocanic acid-modified chitosan (UAC) designed in the previous study was used as a gene carrier. The potential effects of phosphatase and tensin homolog deleted on chromosome 10 ( PTEN) on Akt-related signals and cell cycle regulation were evaluated. Aerosols of UAC-PTEN were delivered into K-ras(LA1) lung cancer model mice through the nose-only inhalation system twice a week for total 4 weeks. Delivered PTEN suppressed lung tumor development significantly through nuclear complex formation between PTEN and p53, suppressing Akt-related signals as well as cell cycle regulation. Together, our results suggest that aerosol delivery of UAC-PTEN may be compatible with noninvasive in vivo gene therapy.
ISSN
0929-1903
Language
English
URI
https://hdl.handle.net/10371/7888
DOI
https://doi.org/10.1038/sj.cgt.7701116
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  • College of Veterinary Medicine
  • Department of Veterinary Medicine
Research Area Nanotoxicology, Veterinary Toxicology

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