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시상하부-뇌하수체-부신계 조절에 대한 Monoamine 신경전달물질의 역할에 관한 연구(1) -Monoamines과 Corticosteroid의 일주기 변동에 관하여 : Roles of Monoamines Neurotransmitters in Regulation of Hypothalamo-Pituitary-Adrenal Axis
DC Field | Value | Language |
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dc.contributor.author | 이정수 | - |
dc.contributor.author | 서유헌 | - |
dc.contributor.author | 박찬웅 | - |
dc.date.accessioned | 2009-08-30T04:46:59Z | - |
dc.date.available | 2009-08-30T04:46:59Z | - |
dc.date.issued | 1982-06 | - |
dc.identifier.citation | Seoul J Med, Vol.23 No.2, pp. 181-187 | - |
dc.identifier.issn | 0582-6802 | - |
dc.identifier.uri | https://hdl.handle.net/10371/8031 | - |
dc.description.abstract | It has been known for many years that several
putative neurotransmitters have been involved both in the control of circadian rhythmicity and stress induced stimulation of hypothalamo-pituitary-adrenal (HPA) system. Most has been learned about the roles of dopamine (DA), norepinephrineCNE), and serotonin(5-HT) on secretion of this pituitary hormone. Despite extensive work on the influence of hypothalamic neurotransmitters on secretion of this hormone in the last 15 years, it is stiII uncertain which transmitters and which pathways play important regulatory roles, but some evidence indicates that a variety of differ' ent transmitters would be involved. The purposes of the present study are to determine that the circadian rhythmicity of the levels of monoaminesCNE, DA, 5- HT) in whole brain and that of plasma corticosterone levels are present and further more to assess correlations between the circadian rhythmicity of the levels of these monoamines and that of plasma corticosterone levels in rats. Rats maintained on a 12-hr photoperiod 0600 to 1800 (CST) followed by 12 hr of darkness. The results are summarized as follow: 1. The mean levels of the plasma corticosterone (expressed as I'g/100ml plasma) showed a peak level at 6:00 PM(38.815) and lowest level at 10:00 AM(24.826). The difference between highest level and lowest level is statistically significant (PZ. The mean levels of 5-HT In whole brain (expressed as I'g/g of brain) showed two peaks at 12:00 AM and at 4:00 AM(0.466, 0.468 respectively), and lowest level at 8:00 PM(O. 370). The difference between the highest level and lowest level is statistically significant (P3. The brain DA levels showed two peaks at 6:00 PM and at 10:00 AM(0.590, 0.577 respectively), reaching the lowest level at 6:00 AM(0.530). The difference between the highest level and lowest level is not statistically significant. 4. The brain NE levels revealed multiple peaks those are not significantly different. 5. No definite correlation between the circadian rhythmicity of brain DA and NE levIes and that of plasma corticosterone levels was observed. but there may be reverse relationship between 5-HT system and plasma corticosterone. | - |
dc.language.iso | ko | - |
dc.publisher | 서울대학교 의과대학 | - |
dc.title | 시상하부-뇌하수체-부신계 조절에 대한 Monoamine 신경전달물질의 역할에 관한 연구(1) -Monoamines과 Corticosteroid의 일주기 변동에 관하여 | - |
dc.title.alternative | Roles of Monoamines Neurotransmitters in Regulation of Hypothalamo-Pituitary-Adrenal Axis | - |
dc.type | SNU Journal | - |
dc.contributor.AlternativeAuthor | Lee, Jeung Soo | - |
dc.contributor.AlternativeAuthor | Suh, Yoo Hun | - |
dc.contributor.AlternativeAuthor | Park, Chan Woong | - |
dc.citation.journaltitle | 서울 의대 잡지 | - |
dc.citation.journaltitle | 서울 의대 학술지 | - |
dc.citation.journaltitle | Seoul Journal of Medicine | - |
dc.citation.endpage | 187 | - |
dc.citation.number | 2 | - |
dc.citation.pages | 181-187 | - |
dc.citation.startpage | 181 | - |
dc.citation.volume | 23 | - |
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