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Functional composite nanofibers of poly(lactide-co-caprolactone) containing gelatin-apatite bone mimetic precipitate for bone regeneration

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dc.contributor.authorJegal, Seung-Hwan-
dc.contributor.authorPark, Jeong-Hui-
dc.contributor.authorKim, Joong-Hyun-
dc.contributor.authorKim, Tae-Il-
dc.contributor.authorKim, Hae-Won-
dc.contributor.authorShin, Ueon Sang-
dc.contributor.authorKim, Tae-Hyun-
dc.date.accessioned2013-01-14T05:40:28Z-
dc.date.available2013-01-14T05:40:28Z-
dc.date.issued2011-04-
dc.identifier.citationACTA BIOMATERIALIA, Vol.7, No.4, pp.1609-1617ko_KR
dc.identifier.issn1742-7061-
dc.identifier.urihttps://hdl.handle.net/10371/80355-
dc.description.abstractFunctional nanofibrous materials composed of gelatin-apatite-poly(lactide-co-caprolactone) (PLCL) were produced using an electrospinning process. A gelatin-apatite precipitate, which mimicked bone extracellular matrix, was homogenized in an organic solvent using various concentrations of PLCL A fibrous structure with approximate diameters of a few hundred nanometers was successfully generated. Apatite nanocrystallines were found to be effectively distributed within the polymeric matrix of the gelatin-PLCL The addition of a small amount of gelatin-apatite into PLCL significantly improved the tensile strength of the nanofiber by a factor of 1.8. Moreover, tissue cell growth on the composite nanofiber was enhanced. Osteogenic differentiation of the cells was significantly stimulated by the composite nanofiber compared with the pure PLCL nanofiber. When implanted in a rat calvarium for 6 weeks the composite nanofiber supported defect closure and new bone formation better than the pure PLCL nanofiber, as deduced from micro-computed tomography and histological analyses. Based on these results, the gelatin-apatite-PLCL composite nanofiber developed in this study is considered to be potentially useful as a bone tissue regeneration matrix. (C) 2010 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.ko_KR
dc.description.sponsorshipThis work was supported by the Priority Research Centers Program (grant no. 2009-0093829) and the World Class University Program (grant no. R31-10069) through the National Research Foundation funded by the Ministry of Education, Science and Technology.-
dc.language.isoenko_KR
dc.publisherELSEVIER SCI LTDko_KR
dc.subjectElectrospun matrixko_KR
dc.subjectApatite-gelatinko_KR
dc.subjectPolymer nanofiberko_KR
dc.subjectOsteoblastic responsesko_KR
dc.subjectBone regenerationko_KR
dc.titleFunctional composite nanofibers of poly(lactide-co-caprolactone) containing gelatin-apatite bone mimetic precipitate for bone regenerationko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor제갈승환-
dc.contributor.AlternativeAuthor박정희-
dc.contributor.AlternativeAuthor김중현-
dc.contributor.AlternativeAuthor김태일-
dc.contributor.AlternativeAuthor김해원-
dc.contributor.AlternativeAuthor신원상-
dc.contributor.AlternativeAuthor김태현-
dc.identifier.doi10.1016/j.actbio.2010.12.003-
dc.citation.journaltitleACTA BIOMATERIALIA-
dc.description.tc9-
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