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Rho-associated kinase (ROCK) inhibition reverses low cell activity on hydrophobic surfaces

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dc.contributor.authorTian, Yu Shun-
dc.contributor.authorKim, Hyun Jung-
dc.contributor.authorKim, Hyun-Man-
dc.date.accessioned2013-01-14T05:52:12Z-
dc.date.available2013-01-14T05:52:12Z-
dc.date.issued2009-08-28-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, Vol.386, No.3, pp.499-503ko_KR
dc.identifier.issn0006-291X-
dc.identifier.urihttps://hdl.handle.net/10371/80369-
dc.description.abstractHydrophobic polymers do not offer an adequate scaffold surface for cells to attach, migrate, proliferate, and differentiate. Thus, hydrophobic scaffolds for tissue engineering have traditionally been physicochemically modified to enhance cellular activity. However, modifying the surface by chemical or physical treatment requires Supplementary engineering procedures. In the present study, regulation of a cell signal transduction pathway reversed the low Cellular activity on a hydrophobic surface without Surface modification. inhibition of Rho-associated kinase (ROCK) by Y-27632 markedly enhanced adhesion, Migration, and proliferation of osteoblastic cells cultured on a hydrophobic polystyrene Surface. ROCK inhibition regulated cell-cycle-related molecules on the hydrophobic Surface. This inhibition also decreased expression of the inhibitors of cyclin-dependent kinases such as p21(cip1) and p27(kip1) and increased expression of cyclin A and D. These results indicate that defective cellular activity on the hydrophobic Surface can be reversed by the control of a cell signal transduction pathway Without physicochemical surface modification. (C) 2009 Elsevier Inc. All rights reserved.ko_KR
dc.description.sponsorshipThis work was supported by a research grant from the Education,
Ministry of Science and Technology, Korea and the Korean
Science and Engineering Foundation through the Intellectual Biointerface Engineering Center (IBEC) at Seoul National University.
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dc.language.isoenko_KR
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCEko_KR
dc.subjectHydrophobicityko_KR
dc.subjectRho-associated kinaseko_KR
dc.subjectY-27632ko_KR
dc.subjectOsteoblastko_KR
dc.subjectCell cycleko_KR
dc.subjectMigrationko_KR
dc.subjectAdhesionko_KR
dc.subjectTissue engineeringko_KR
dc.subjectBiomaterialko_KR
dc.titleRho-associated kinase (ROCK) inhibition reverses low cell activity on hydrophobic surfacesko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor김현정-
dc.contributor.AlternativeAuthor김현만-
dc.identifier.doi10.1016/j.bbrc.2009.06.087-
dc.citation.journaltitleBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.description.tc7-
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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