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Osteoconductive and degradable electrospun nonwoven poly(epsilon-caprolactone)/CaO-SiO2 gel composite fabric

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dc.contributor.authorSeol, Yang-Jo-
dc.contributor.authorKim, Kyoung-Hwa-
dc.contributor.authorKim, In Ae-
dc.contributor.authorRhee, Sang-Hoon-
dc.date.accessioned2013-01-14T06:24:36Z-
dc.date.available2013-01-14T06:24:36Z-
dc.date.issued2010-08-
dc.identifier.citationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A; Vol.94A, No.2, pp.649-659ko_KR
dc.identifier.issn1549-3296-
dc.identifier.urihttp://hdl.handle.net/10371/80410-
dc.description.abstractA nonwoven ceramic/polymer composite fabric composed of randomly mixed bioactive and fast degradable CaO-SiO2 gel fibers and biodegradable poly(epsilon-caprolactone) (PCL) fibers is prepared with a simultaneous electrospinning method for potential use as bone grafting materials. A 17% PCL solution is prepared using 1,1,3,3-hexafluoro-2-propanol as the solvent, whereas the CaO-SiO2 gel solution is prepared via a condensation reaction following the hydrolysis of tetraethyl orthosilicate. PCL and CaO-SiO2 gel solutions are spun simultaneously with two separate nozzles. As controls, pure PCL and CaO-SiO2 gel nonwoven fabrics are also made by the same methods. The three nonwoven fabrics were exposed to simulated body fluid for 1 week and resulted in the deposition of a layer of apatite crystals on the surfaces of both the CaO-SiO2 gel and PCL/CaO-SiO2 gel composite fabrics, but not on the PCL fabric. A tensile strength test showed that the fracture behavior of the CaO-SiO2 gel fabric was brittle, that of the PCL fabric was ductile-tough, and that of the PCL/CaO-SiO2 gel composite fabric was intermediate between that of the CaO-SiO2 gel and PCL fabrics. Our in vivo tests showed that the CaO-SiO2 gel and PCL/CaO-SiO2 gel composite fabrics had good osteoconductivity and fast degradation rates in calvarial defects of New Zealand white rabbits within 4 weeks, in contrast to the pure PCL fabric. Together, these results suggest that the composite fabric composed of PCL and CaO-SiO2 gel fibers must have a great potential for use in applications such as bone grafting because of its good osteoconductivity and adequate mechanical properties. (C) 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 94A: 649-659, 2010ko_KR
dc.language.isoenko_KR
dc.publisherWILEY-BLACKWELLko_KR
dc.subjectpoly(epsilon-caprolactone)ko_KR
dc.subjectCaO-SiO2 gelko_KR
dc.subjectcompositeko_KR
dc.subjectosteoconductivityko_KR
dc.subjectdegradabilityko_KR
dc.subjectelectrospinningko_KR
dc.titleOsteoconductive and degradable electrospun nonwoven poly(epsilon-caprolactone)/CaO-SiO2 gel composite fabricko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor설양조-
dc.contributor.AlternativeAuthor김경화-
dc.contributor.AlternativeAuthor김인애-
dc.contributor.AlternativeAuthor이상훈-
dc.identifier.doi10.1002/jbm.a.32738-
dc.citation.journaltitleJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A-
dc.description.tc5-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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