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Electrospun nanofibers composed of poly(ε-caprolactone) and polyethylenimine for tissue engineering applications

Cited 40 time in Web of Science Cited 41 time in Scopus
Authors
Kim, Jang Ho; Choung, Pill-Hoon; Kim, In Yong; Lim, Ki Taek; Choung, Yun-Hoon; Chung, Jong Hoon; Cho, Chong-Su; Son, Hyun Mok
Issue Date
2009-06-01
Publisher
ELSEVIER SCIENCE BV
Citation
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, Vol.29, No.5, pp.1725-1731
Keywords
NanofibersHydrophilicityPoly(ε-caprolactone)Tissue engineeringPolyethylenimine
Abstract
Poly(ε-caprolactone) (PCL) electrospun nanofibers have been reported as a scaffold for tissue engineering application. However, high hydrophobicity of PCL limits use of functional scaffold. In this Study, PCL/polyethylenimine (PEI) blend electrospun nanofibers were prepared to overcome the limitation of PCL ones because the PEI as a cationic polymer can increase cell adhesion and can improve the electrospinnability of PCL. The structure, mechanical properties and biological activity of the PCL/PEI electrospun nanofibers were studied. The diameters of the PCL/PEI nanofibers ranged from 150.4 +/- 33 to 220.4 +/- 32 nm. The PCL/PEI nanofibers showed suitable mechanical properties with adequate porosity and increased hydrophilic behavior. The cell adhesion and cell proliferation of PCL nanofibers; were increased by blending with PEI due to the hydrophilic properties of PEI. (C) 2009 Elsevier B.V. All rights reserved.
ISSN
0928-4931
Language
English
URI
http://hdl.handle.net/10371/80491
DOI
https://doi.org/10.1016/j.msec.2009.01.023
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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