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Osteoblast-Specific Expression of MEF Induces Osteopenia Through Downregulation of Osteoblastogenesis and Upregulation of Osteoclastogenesis

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dc.contributor.authorSeul, Keyung-Jo-
dc.contributor.authorCho, Hye-Sim-
dc.contributor.authorHeo, Sun-Hee-
dc.contributor.authorBaek, Wook-Young-
dc.contributor.authorPark, Eui Kyun-
dc.contributor.authorRyoo, Hyun-Mo-
dc.contributor.authorCho, Je-Yoel-
dc.contributor.authorChoi, Je-Yong-
dc.contributor.authorKim, Jung-Eun-
dc.date.accessioned2013-01-15T02:07:40Z-
dc.date.available2013-01-15T02:07:40Z-
dc.date.issued2011-02-
dc.identifier.citationJOURNAL OF BONE AND MINERAL RESEARCH, Vol.26, No.2, pp.341-350ko_KR
dc.identifier.issn0884-0431-
dc.identifier.urihttps://hdl.handle.net/10371/80555-
dc.description.abstractIn bone remodeling, various transcriptional factors are involved, and the deficiency or overexpression of some of these factors results in bone defects. Myeloid elf-1-like factor (MEF) is one of the Ets transcription factors that control the expression of genes that are critical for biologic processes such as cell proliferation, differentiation, and death. Previously, we reported that MEF promotes cell proliferation and functions as a negative regulator of osteogenic differentiation by interacting directly with Runx2 and suppressing its transcriptional activity. To investigate the in vivo function of MEF in bone formation and bone remodeling in vivo, we generated transgenic mice that overexpress MEF in osteoblasts under the control of the 2.3-kb Col1 alpha 1 promoter, named Col1 alpha 1-MEF. Femoral bone in Col1 alpha 1-MEF transgenic mice exhibited low bone mass with fewer trabecular bones and thinner and less developed cortical bones. The mineralized volume fraction (BV/TV) and bone- forming rate (BFR) were remarkably decreased to about 63% and 40%, respectively, in 6-week-old MEF transgenic mice compared with wild-type mice. In addition, reduced bone mineral density was observed in lumbar vertebrae of Col1 alpha 1-MEF transgenic mice. The number of TRACP(+) osteoclasts was increased in Col1 alpha 1-MEF transgenic mice and MEF-overexpressing MC3T3-E1 cells. All these in vivo results suggest that MEF suppresses bone formation by osteoblasts and facilitates bone resorption by activating osteoclasts indirectly. (C) 2011 American Society for Bone and Mineral Research.ko_KR
dc.description.sponsorshipThis work was supported by the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (Grant No.
A010252) and the Ministry of Education Science and Technology (MEST), Republic of Korea (Grant Nos. 2006-2002770, 2006-2004608, and 2009-0084045).
ko_KR
dc.language.isoenko_KR
dc.publisherWILEY-BLACKWELLko_KR
dc.subjectMEF (MYELOID ELF-1-LIKE FACTOR)ko_KR
dc.subjectTRANSGENIC MICEko_KR
dc.subjectBONE REMODELINGko_KR
dc.subjectBONE FORMATIONko_KR
dc.subjectCOL1 alpha 1 PROMOTERko_KR
dc.titleOsteoblast-Specific Expression of MEF Induces Osteopenia Through Downregulation of Osteoblastogenesis and Upregulation of Osteoclastogenesisko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor설경조-
dc.contributor.AlternativeAuthor조혜심-
dc.contributor.AlternativeAuthor허선희-
dc.contributor.AlternativeAuthor백욱영-
dc.contributor.AlternativeAuthor박의균-
dc.contributor.AlternativeAuthor류현모-
dc.contributor.AlternativeAuthor조제열-
dc.contributor.AlternativeAuthor최제용-
dc.contributor.AlternativeAuthor김정은-
dc.identifier.doi10.1002/jbmr.208-
dc.citation.journaltitleJOURNAL OF BONE AND MINERAL RESEARCH-
dc.description.tc2-
Appears in Collections:
College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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