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Eugenol inhibits K+ currents in trigeminal ganglion neurons
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, H.Y. | - |
dc.contributor.author | Park, C.-K. | - |
dc.contributor.author | Jung, S.J. | - |
dc.contributor.author | Choi, S.-Y. | - |
dc.contributor.author | Park, K. | - |
dc.contributor.author | Oh, S.B. | - |
dc.contributor.author | Kim, J.S. | - |
dc.contributor.author | Lee, S.J. | - |
dc.date.accessioned | 2013-01-21T03:49:29Z | - |
dc.date.available | 2013-01-21T03:49:29Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Journal of Dental Research; Vol.86, No.9, pp.898-902 | ko_KR |
dc.identifier.issn | 0022-0345 | - |
dc.identifier.uri | https://hdl.handle.net/10371/80836 | - |
dc.description.abstract | Eugenol, a natural capsaicin congener, is widely used in dentistry. Eugenol inhibits voltage-activated Na + and Ca 2+ channels in a transient receptor potential vanilloid 1 (TRPV1)-independent manner. We hypothesized that eugenol also inhibits voltage-gated K + currents, and investigated this in rat trigeminal ganglion neurons and in a heterologous system using whole-cell patch clamping. Eugenol inhibited voltage-gated K + currents, and the inhibitory effects of eugenol were observed in both capsaicin-sensitive and capsaicin-insensitive neurons. Pre-treatment with capsazepine, a well-known antagonist of TRPV1, failed to block the inhibitory effects of eugenol on K + currents, suggesting no involvement of TRPV1. Eugenol inhibited human Kv1.5 currents stably expressed in Ltk - cells, where TRPV1 is not endogenously expressed. We conclude that eugenol inhibits voltage-gated K + currents in a TRPV1-independent manner. The inhibition of voltage-gated K + currents is likely to contribute to the irritable action of eugenol. Abbreviations: human Kv 1.5 channel, hKv1.5; transient receptor potential vanilloid 1, TRPV1. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | SAGE | ko_KR |
dc.subject | Eugenol | ko_KR |
dc.subject | Kv1.5 | ko_KR |
dc.subject | Trigeminal ganglion neurons | ko_KR |
dc.subject | Voltage-gated K + currents | ko_KR |
dc.title | Eugenol inhibits K+ currents in trigeminal ganglion neurons | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 박철규 | - |
dc.contributor.AlternativeAuthor | 정승준 | - |
dc.contributor.AlternativeAuthor | 최세영 | - |
dc.contributor.AlternativeAuthor | 박경표 | - |
dc.contributor.AlternativeAuthor | 오석배 | - |
dc.contributor.AlternativeAuthor | 김중수 | - |
dc.contributor.AlternativeAuthor | 이성중 | - |
dc.identifier.doi | 10.1177/154405910708600918 | - |
dc.citation.journaltitle | Journal of Dental Research | - |
dc.description.tc | 12 | - |
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