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Polymorphisms in the Matrilin-1 gene and risk of mandibular prognathism in Koreans
Cited 45 time in
Web of Science
Cited 50 time in Scopus
- Authors
- Issue Date
- 2010
- Publisher
- SAGE
- Citation
- Journal of Dental Research; Vol.89, No.11, pp.1203-1207
- Keywords
- mandibular prognathism ; Matrilin-1 ; SNP ; polymorphism
- Abstract
- Previous linkage analysis of an Asian population proposed possible candidate genes for mandibular prognathism, such as Matrilin-1 (cartilage matrix protein). To investigate the association between the single-nucleotide polymorphisms (SNPs) in Matrilin-1 and mandibular prognathism, we investigated three sequence variants (-158 T>C, 7987 G>A, 8572 C>T) in 164 mandibular prognathism patients and 132 control individuals with a normal occlusion. The results showed that the 8572 TT genotypes in Matrilin-1 showed increased risk of mandibular prognathism (OR = 9.28, 95% Cl = 1.19??97.57, P < 0.05), whereas the 7987 AA genotype showed a protective effect for mandibular prognathism (OR = 0.16, 95% Cl = 0.05??.47, P < 0.05). Genotyping results showed that the Matrilin-1 polymorphism haplotype TGC (ht4; 158T, 7987G, and 8572C alleles) had a pronounced risk effect for mandibular prognathism compared with controls (OR = 5.16, 95% Cl = 2.03??3.93, P < 0.01). The results suggest that polymorphisms in Matrilin-1 could be used as a marker for genetic susceptibility to mandibular prognathism. ⓒ 2010 International & American Associations for Dental Research.
- ISSN
- 0022-0345
- Language
- English
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