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SHED repair critical-size calvarial defects in mice
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Seo, B.M. | - |
dc.contributor.author | Sonoyama, W. | - |
dc.contributor.author | Yamaza, T. | - |
dc.contributor.author | Coppe, C. | - |
dc.contributor.author | Akiyama, K. | - |
dc.contributor.author | Shi, S. | - |
dc.contributor.author | Lee, J.S. | - |
dc.contributor.author | Kikuiri, T. | - |
dc.date.accessioned | 2013-01-22T06:39:24Z | - |
dc.date.available | 2013-01-22T06:39:24Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Oral Diseases; Vol.14, No.5, pp.428-434 | ko_KR |
dc.identifier.issn | 1354-523X | - |
dc.identifier.uri | https://hdl.handle.net/10371/80973 | - |
dc.description.abstract | Objective: Stem cells from human exfoliated deciduous teeth (SHED) are a population of highly proliferative postnatal stem cells capable of differentiating into odontoblasts, adipocytes, neural cells, and osteo-inductive cells. To examine whether SHED-mediated bone regeneration can be utilized for therapeutic purposes, we used SHED to repair critical-size calvarial defects in immunocompromised mice. Materials and methods: We generated calvarial defects and transplanted SHED with hydroxyapatite/tricalcium phosphate as a carrier into the defect areas. Results: SHED were able to repair the defects with substantial bone formation. Interestingly, SHED-mediated osteogenesis failed to recruit hematopoietic marrow elements that are commonly seen in bone marrow mesenchymal stem cell-generated bone. Furthermore, SHED were found to co-express mesenchymal stem cell marker, CC9/MUC18/CD146, with an array of growth factor receptors such as transforming growth factor beta receptor I and II, fibroblast growth factor receptor I and III, and vascular endothelial growth factor receptor I, implying their comprehensive differentiation potential. Conclusions: Our data indicate that SHED, derived from neural crest cells, may select unique mechanisms to exert osteogenesis. SHED might be a suitable resource for orofacial bone regeneration. ⓒ 2007 Blackwell Munksgaard. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | John Wiley and Sons | ko_KR |
dc.subject | Bone | ko_KR |
dc.subject | Regeneration | ko_KR |
dc.subject | Stem cells from human exfoliated deciduous teeth (SHED) | ko_KR |
dc.subject | Osteoblast | ko_KR |
dc.title | SHED repair critical-size calvarial defects in mice | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 서병무 | - |
dc.identifier.doi | 10.1111/j.1601-0825.2007.01396.x | - |
dc.citation.journaltitle | Oral Diseases | - |
dc.description.tc | 37 | - |
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