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Bone regeneration by bioactive hybrid membrane containing FGF2 within rat calvarium
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hong, Ki Seok | - |
dc.contributor.author | Kim, Eun-Cheol | - |
dc.contributor.author | Bang, So-Hee | - |
dc.contributor.author | Chung, Chin-Hyung | - |
dc.contributor.author | Hyun, Jung Keun | - |
dc.contributor.author | Jang, Jun-Hyeog | - |
dc.contributor.author | Kim, Hae-Won | - |
dc.contributor.author | Kim, Tae-Il | - |
dc.contributor.author | Lee, Hae-Hyoung | - |
dc.contributor.author | Lee, Young Il | - |
dc.date.accessioned | 2013-01-23T00:33:40Z | - |
dc.date.available | 2013-01-23T00:33:40Z | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Journal of Biomedical Materials Research - Part A; Vol.94, No.4, pp.1187-1194 | ko_KR |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | https://hdl.handle.net/10371/80998 | - |
dc.description | The definitive version is available at www3.interscience.wiley.com | ko_KR |
dc.description.abstract | This study examined the bone regeneration potential of a novel hybrid membrane consisting of collagen and nano-bioactive glass (nBG) incorporating basic fibroblast growth factor (FGF2) for use in guided bone regeneration. nBG was added to a reconstitution of collagen at a concentration of 30%, and the hybrid was formulated into a thin membrane. FGF2 (50 μg/ml) was adsorbed to the hybrid membrane. This level of FGF2 was found to be the optimal concentration to stimulate osteoblastic differentiation in vitro. Three membrane groups, including pure collagen, collagen-nBG hybrid and its combination with FGF2 were implanted within a rat calvarium defect (ϕ = 5 mm) for a period of 3 weeks. Histomorphometric analysis was carried out to evaluate the bone regeneration within the defect. The results showed that the defect in the collagen-nBG-FGF2 membrane was recovered almost completely, while partial recovery was observed in the other membrane groups (collagen and collagen-BG). However, there was little defect recovery in the blank control. The new bone formation was as high as ∼60, ∼45, and ∼30% of the defect treated with the collagen-nBG-FGF2, collagen-BG, and collagen, respectively, whilst only 4% of new bone was observed in the blank control. Overall, the nBG was shown to stimulate bone formation of the collagen membrane, and FGF2 synergistically accelerated the bone regeneration within a rat calvarium defect. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010. | ko_KR |
dc.language.iso | en | ko_KR |
dc.publisher | WILEY PERIODICALS | ko_KR |
dc.subject | Bone regeneration | ko_KR |
dc.subject | Nano-bioactive glass | ko_KR |
dc.subject | Guided membrane | ko_KR |
dc.subject | Fibroblast growth factor | ko_KR |
dc.subject | Collagen | ko_KR |
dc.title | Bone regeneration by bioactive hybrid membrane containing FGF2 within rat calvarium | ko_KR |
dc.type | Article | ko_KR |
dc.contributor.AlternativeAuthor | 홍기석 | - |
dc.contributor.AlternativeAuthor | 김은철 | - |
dc.contributor.AlternativeAuthor | 방소희 | - |
dc.contributor.AlternativeAuthor | 정진형 | - |
dc.contributor.AlternativeAuthor | 현정근 | - |
dc.contributor.AlternativeAuthor | 장준혁 | - |
dc.contributor.AlternativeAuthor | 김해원 | - |
dc.contributor.AlternativeAuthor | 김태일 | - |
dc.contributor.AlternativeAuthor | 이해형 | - |
dc.contributor.AlternativeAuthor | 이영일 | - |
dc.identifier.doi | 10.1002/jbm.a.32799 | - |
dc.citation.journaltitle | Journal of Biomedical Materials Research - Part A | - |
dc.description.tc | 6 | - |
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