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Bone regeneration by bioactive hybrid membrane containing FGF2 within rat calvarium

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dc.contributor.authorHong, Ki Seok-
dc.contributor.authorKim, Eun-Cheol-
dc.contributor.authorBang, So-Hee-
dc.contributor.authorChung, Chin-Hyung-
dc.contributor.authorHyun, Jung Keun-
dc.contributor.authorJang, Jun-Hyeog-
dc.contributor.authorKim, Hae-Won-
dc.contributor.authorKim, Tae-Il-
dc.contributor.authorLee, Hae-Hyoung-
dc.contributor.authorLee, Young Il-
dc.date.accessioned2013-01-23T00:33:40Z-
dc.date.available2013-01-23T00:33:40Z-
dc.date.issued2010-
dc.identifier.citationJournal of Biomedical Materials Research - Part A; Vol.94, No.4, pp.1187-1194ko_KR
dc.identifier.issn1549-3296-
dc.identifier.urihttps://hdl.handle.net/10371/80998-
dc.descriptionThe definitive version is available at www3.interscience.wiley.comko_KR
dc.description.abstractThis study examined the bone regeneration potential of a novel hybrid membrane consisting of collagen and nano-bioactive glass (nBG) incorporating basic fibroblast growth factor (FGF2) for use in guided bone regeneration. nBG was added to a reconstitution of collagen at a concentration of 30%, and the hybrid was formulated into a thin membrane. FGF2 (50 μg/ml) was adsorbed to the hybrid membrane. This level of FGF2 was found to be the optimal concentration to stimulate osteoblastic differentiation in vitro. Three membrane groups, including pure collagen, collagen-nBG hybrid and its combination with FGF2 were implanted within a rat calvarium defect (ϕ = 5 mm) for a period of 3 weeks. Histomorphometric analysis was carried out to evaluate the bone regeneration within the defect. The results showed that the defect in the collagen-nBG-FGF2 membrane was recovered almost completely, while partial recovery was observed in the other membrane groups (collagen and collagen-BG). However, there was little defect recovery in the blank control. The new bone formation was as high as ∼60, ∼45, and ∼30% of the defect treated with the collagen-nBG-FGF2, collagen-BG, and collagen, respectively, whilst only 4% of new bone was observed in the blank control. Overall, the nBG was shown to stimulate bone formation of the collagen membrane, and FGF2 synergistically accelerated the bone regeneration within a rat calvarium defect. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part A, 2010.ko_KR
dc.language.isoenko_KR
dc.publisherWILEY PERIODICALSko_KR
dc.subjectBone regenerationko_KR
dc.subjectNano-bioactive glassko_KR
dc.subjectGuided membraneko_KR
dc.subjectFibroblast growth factorko_KR
dc.subjectCollagenko_KR
dc.titleBone regeneration by bioactive hybrid membrane containing FGF2 within rat calvariumko_KR
dc.typeArticleko_KR
dc.contributor.AlternativeAuthor홍기석-
dc.contributor.AlternativeAuthor김은철-
dc.contributor.AlternativeAuthor방소희-
dc.contributor.AlternativeAuthor정진형-
dc.contributor.AlternativeAuthor현정근-
dc.contributor.AlternativeAuthor장준혁-
dc.contributor.AlternativeAuthor김해원-
dc.contributor.AlternativeAuthor김태일-
dc.contributor.AlternativeAuthor이해형-
dc.contributor.AlternativeAuthor이영일-
dc.identifier.doi10.1002/jbm.a.32799-
dc.citation.journaltitleJournal of Biomedical Materials Research - Part A-
dc.description.tc6-
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College of Dentistry/School of Dentistry (치과대학/치의학대학원)Dept. of Dentistry (치의학과)Journal Papers (저널논문_치의학과)
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